ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2010
The RCK2 domain uses a coordination site present in Kir channels to confer sodium sensitivity to Slo2.2 channels.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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Who cites it
48 citing papers in PubMed.
- Mechanism of Kch activation by ZnPNAS nexus · 2026Article
- Unraveling the mechanisms of slack channel mutations in epileptic disorders.Acta epileptologica · 2026Review
- TrkA ofMicrobiology (Reading, England) · 2025Article
- Review
- Structure-Activity Relationship Studies in a Series of 2-Aryloxy-Molecules (Basel, Switzerland) · 2024Article
- A molecular switch in RCK2 triggers sodium-dependent activation of KBiophysical journal · 2024Article
- Structure-Activity Relationship Studies in a Series of Xanthine Inhibitors of SLACK Potassium Channels.Molecules (Basel, Switzerland) · 2024Article
- Structural basis and synergism of ATP and NaNature communications · 2024Article
- Coupling of Slack and NaeLife · 2024Article
- Design, synthesis, and biological evaluation of a novel series of 1,2,4-oxadiazole inhibitors of SLACK potassium channels: Identification of in vitro tool VU0935685.Bioorganic & medicinal chemistry · 2023Article
- Structure-activity relationship studies in a new series of 2-amino-N-phenylacetamide inhibitors of Slack potassium channels.Bioorganic & medicinal chemistry letters · 2022Article
- Therapeutic Drug Monitoring of Quinidine in Pediatric Patients withPharmaceutics · 2022Article
- Primary nutrient sensors in plants.iScience · 2022Review
- The Slack Channel Regulates Anxiety-Like Behaviors via Basolateral Amygdala Glutamatergic Projections to Ventral Hippocampus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Small-molecule inhibitors of Slack potassium channels as potential therapeutics for childhood epilepsies.Pharmaceutical patent analyst · 2022Review
- Double-edged Role of KCurrent neuropharmacology · 2022Review
- The Slack Channel Deletion Causes Mechanical Pain Hypersensitivity in Mice.Frontiers in molecular neuroscience · 2022Article
- Review
- Coconut genome assembly enables evolutionary analysis of palms and highlights signaling pathways involved in salt tolerance.Communications biology · 2021Article
- Functional Coupling of Slack Channels and P2X3 Receptors Contributes to Neuropathic Pain Processing.International journal of molecular sciences · 2021Article
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5 authors.
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Abstract
Slo2 Na(+)-activated potassium channels are widely expressed in neurons and other cells, such as kidney, heart, and skeletal muscle. Although their important physiological roles continue to be appreciated, molecular determinants responsible for sensing intracellular Na(+) remain unknown. Here we report identification of an Na(+) regulatory site, similar to an Na(+) coordination motif described in Kir channels, localized in the RCK2 domain of Slo2.2 channels. Molecular simulations of the homology-modeled Slo2.2 RCK2 domain provided structural insights into the organization of this Na(+) coordination site. Furthermore, free energy calculations reproduced the experimentally derived monovalent cation selectivity. Our results suggest that Slo2.2 and Kir channels share a similar mechanism to coordinate Na(+). The localization of an Na(+) sensor within the RCK2 domain of Slo2.2 further supports the role of RCK (regulators of conductance of K(+)) domains of Slo channels in coupling ion sensing to channel gating.
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