ArticleJournal of clinical microbiology2010
Detection of human parechoviruses from clinical stool samples in Aichi, Japan.
Article in Journal of clinical microbiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 93 citations in OpenAlex.
- Neonatal Sepsis Caused by Human Parechovirus Type A3 With Marked Hyperferritinemia: A Case Report.Case reports in pediatrics · 2025Article
- Prevalence and genetic diversity of Parechovirus.Virus research · 2024Article
- An outbreak investigation of parechovirus-A3 in a newborn nursery.Infection control and hospital epidemiology · 2024Observational
- Parechovirus and enteroviruses among young infants with sepsis in Iran.Iranian journal of microbiology · 2021Article
- Rapid molecular diagnosis of Parechovirus infection using the reverse transcription loop-mediated isothermal amplification technique.PloS one · 2021Article
- The Identification and Genetic Characterization of Parechovirus Infection Among Pediatric Patients With Wide Clinical Spectrum in Chongqing, China.Frontiers in microbiology · 2021Article
- Clinical Characteristics of Epidemic Myalgia Associated with Human Parechovirus Type 3 during the Summer of 2019.Internal medicine (Tokyo, Japan) · 2020Article
- Review
- High frequency and diversity of parechovirus A in a cohort of Malawian children.Archives of virology · 2019Article
- Epidemiology and genetic diversity of human parechoviruses circulating among children hospitalised with acute gastroenteritis in Pune, Western India: a 5-years study.Epidemiology and infection · 2018Article
- Human Parechovirus: an Increasingly Recognized Cause of Sepsis-Like Illness in Young Infants.Clinical microbiology reviews · 2018Review
- Seropositivity and epidemiology of human parechovirus types 1, 3, and 6 in Japan.Epidemiology and infection · 2016Article
- Role of Maternal Antibodies in Infants with Severe Diseases Related to Human Parechovirus Type 3.Emerging infectious diseases · 2015Article
- Characteristics and outcomes of human parechovirus infection in infants (2008-2012).European journal of pediatrics · 2015Article
- Viral etiologies of acute dehydrating gastroenteritis in pakistani children: confounding role of parechoviruses.Viruses · 2015Article
- Epidemiology of human parechovirus, Aichi virus and salivirus in fecal samples from hospitalized children with gastroenteritis in Hong Kong.Virology journal · 2014Article
- Genotyping of human parechoviruses in Iranian young children with aseptic meningitis and sepsis-like illness.Journal of neurovirology · 2013Article
- Etiology of viral gastroenteritis in children <5 years of age in the United States, 2008-2009.The Journal of infectious diseases · 2013Article
- Two cases of sepsis-like illness in infants caused by human parechovirus traced back to elder siblings with mild gastroenteritis and respiratory symptoms.Journal of clinical microbiology · 2013Article
- Human parechovirus genotypes -10, -13 and -15 in Pakistani children with acute dehydrating gastroenteritis.PloS one · 2013Article
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Between April 1999 and March 2008, a total of 4,976 stool specimens collected from patients with suspected viral infection through infectious agent surveillance in Aichi, Japan, were tested for the presence of human parechoviruses (HPeVs). We detected HPeVs in 110 samples by either cell culture, reverse transcriptase PCR (RT-PCR), or both. Serotyping either by neutralization test or by nucleotide sequence determination and phylogenetic analysis of the VP1 region and 5' untranslated region (5'UTR) regions revealed that 63 were HPeV type 1 (HPeV-1), followed by 44 HPeV-3 strains, 2 HPeV-4 strains, and 1 HPeV-6 strain. The high nucleotide and amino acid sequence identities of the Japanese HPeV-3 isolates in 2006 to the strains previously reported from Canada and Netherlands confirmed the worldwide prevalence of HPeV-3 infection. Ninety-seven percent of the HPeV-positive patients were younger than 3 years, and 86.2% younger than 12 months. The clinical diagnoses of HPeV-positive patients were gastroenteritis, respiratory illness, febrile illness, exanthema, "hand, foot, and mouth disease," aseptic meningitis, and herpangina. Among 49 HPeV-positive patients with gastroenteritis, 35 were positive with HPeV-1 and 12 with HPeV-3, and out of 25 with respiratory illness, 11 were positive with HPeV-1 and 14 with HPeV-3. HPeV-3 seemed to be an important etiological agent of respiratory infection of children. While HPeV-1 was detected predominantly during fall and winter, the majority of the HPeV-3 cases were detected during summer and fall. A different pattern of clinical manifestations as well as seasonality suggested that there are different mechanisms of pathogenesis between HPeV-1 and HPeV-3 infections.
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