ArticleJournal of clinical microbiology2010
Genetic diversity and virulence profiles of Escherichia coli isolates causing spontaneous bacterial peritonitis and bacteremia in patients with cirrhosis.
Article in Journal of clinical microbiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 2 of them syntheses that pooled it.
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Who cites it
37 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Global Extraintestinal Pathogenic Escherichia coli (ExPEC) Lineages.Clinical microbiology reviews · 2019Pooled it
- Epidemic potential of Escherichia coli ST131 and Klebsiella pneumoniae ST258: a systematic review and meta-analysis.BMJ open · 2016Pooled it
- Targeted inhibition of pathobiont virulence factor mitigates alcohol-associated liver disease.Cell host & microbe · 2025Article
- Article
- Antibiotic Resistance among Gastrointestinal Bacteria in Broilers: A Review Focused onAnimals : an open access journal from MDPI · 2023Review
- Molecular Epidemiology and Presence of Hybrid PathogenicMicroorganisms · 2022Article
- Intestinal virome and therapeutic potential of bacteriophages in liver disease.Journal of hepatology · 2021Review
- Molecular epidemiology of blaAnnals of clinical microbiology and antimicrobials · 2021Article
- Bloodstream Infections Caused by Extended-Spectrum Beta-Lactamase-ProducingPathogens (Basel, Switzerland) · 2021Article
- Inhibition of Antimicrobial-ResistantFrontiers in microbiology · 2021Article
- Genetic and Virulence Characteristics of a Hybrid Atypical Enteropathogenic and UropathogenicFrontiers in cellular and infection microbiology · 2020Article
- Pneumonia-Specific Escherichia coli with Distinct Phylogenetic and Virulence Profiles, France, 2012-2014.Emerging infectious diseases · 2019Article
- UropathogenicProceedings of the National Academy of Sciences of the United States of America · 2019Article
- Snapshot of Phylogenetic Groups, Virulence, and Resistance Markers inBioMed research international · 2019Article
- Discovery ofmSphere · 2018Article
- Genome-Wide Identification of Fitness Factors in Mastitis-Associated Escherichia coli.Applied and environmental microbiology · 2018Article
- The gut microbiome and liver cancer: mechanisms and clinical translation.Nature reviews. Gastroenterology & hepatology · 2017Review
- The occurrence of ESBL-producing Escherichia coli carrying aminoglycoside resistance genes in urinary tract infections in Saudi Arabia.Annals of clinical microbiology and antimicrobials · 2017Article
- Phylogenetic, virulence and antibiotic resistance characteristics of commensal strain populations of Escherichia coli from community subjects in the Paris area in 2010 and evolution over 30 years.Microbiology (Reading, England) · 2016Article
- Gut Colonization of Healthy Children and Their Mothers With Pathogenic Ciprofloxacin-Resistant Escherichia coli.The Journal of infectious diseases · 2015Article
Corrections and comments
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Authors and funding
9 authors.
Funding
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Abstract
Among patients with cirrhosis, infections caused by Escherichia coli organisms that translocate from the gut are a frequent and severe complication. One hundred ten E. coli isolates from 110 cirrhotic patients with spontaneous bacterial peritonitis and/or spontaneous bacteremia were characterized for their phylogenetic group and virulence genotype (34 extraintestinal virulence factor genes). Genetic relatedness was investigated by enterobacterial repetitive intergenic consensus sequence type 2 (ERIC-2) PCR typing and multilocus sequence typing. Phylogenetic groups A, B1, B2, and D accounted for 24%, 4%, 48%, and 24% of the population, respectively. Overall, 68 distinct ERIC-2 profiles were encountered. Eleven clonal groups, represented by multiple isolates (2 to 11) from the same sequence type (ST) or sequence type complex, were identified. These clonal groups accounted for 54 (49%) isolates overall. Membership in one of these clonal groups was more frequent among B2 isolates than non-B2 isolates (67% versus 32%, P < 0.001). The most frequent sequence types were ST95 (n = 13) and ST73 (n = 8), followed by the ST14 and ST10 complexes (n = 7). ST131 and ST69 were represented by three isolates each. Clonal group-associated isolates exhibited a greater prevalence of 11 virulence genes, including pap elements, than the other isolates. However, no association between clonal groups and host factors, type of infection, or mortality was observed. In conclusion, E. coli isolates causing spontaneous bacterial peritonitis and bacteremia in cirrhotic patients are genetically diverse. However, approximately half of the isolates belong to familiar clonal groups and exhibit extensive virulence profiles that may be associated with greater invasive potential.
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