ArticleAmerican journal of physiology. Renal physiology2010
Adenosine A(2) receptors modulate tubuloglomerular feedback.
Article in American journal of physiology. Renal physiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 31 citations in OpenAlex.
- Renoprotective effects of empagliflozin are linked to activation of the tubuloglomerular feedback mechanism and blunting of the complement system.American journal of physiology. Cell physiology · 2023Article
- Adenosine stimulates the basolateral 50 pS KFrontiers in physiology · 2023Article
- Identification and function of adenosine A3 receptor in afferent arterioles.American journal of physiology. Renal physiology · 2015Article
- Renal autoregulation in health and disease.Physiological reviews · 2015Review
- Blood pressure, heart rate and tubuloglomerular feedback in A1AR-deficient mice with different genetic backgrounds.Acta physiologica (Oxford, England) · 2015Article
- Purinergic signalling in the kidney in health and disease.Purinergic signalling · 2014Review
- Salt sensitivity of tubuloglomerular feedback in the early remnant kidney.American journal of physiology. Renal physiology · 2014Article
- Direct assessment of tubuloglomerular feedback responsiveness in connexin 40-deficient mice.American journal of physiology. Renal physiology · 2013Article
- Role of the adenosine(2A) receptor-epoxyeicosatrienoic acid pathway in the development of salt-sensitive hypertension.Prostaglandins & other lipid mediators · 2012Review
- Pharmacological targets in the renal peritubular microenvironment: implications for therapy for sepsis-induced acute kidney injury.Pharmacology & therapeutics · 2012Review
- Stimulation of A(₂a) adenosine receptor abolishes the inhibitory effect of arachidonic acid on the basolateral 50-pS K channel in the thick ascending limb.American journal of physiology. Renal physiology · 2011Article
- Adenosine A2A receptor activation attenuates tubuloglomerular feedback responses by stimulation of endothelial nitric oxide synthase.American journal of physiology. Renal physiology · 2011Article
- Maintained tubuloglomerular feedback responses during acute inhibition of P2 purinergic receptors in mice.American journal of physiology. Renal physiology · 2011Article
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3 authors at 2 institutions in 1 country.
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Abstract
Adenosine can mediate the tubuloglomerular (TGF) response via activation of A(1) receptors on the afferent arteriole, but both adenosine A(1) and A(2) receptors can regulate preglomerular resistance. We tested the hypothesis that adenosine A(2) receptors offset the effect of A(1) receptors and modulate the TGF. Maximal TGF responses were measured in male Sprague-Dawley rats as changes in proximal stop-flow pressure (DeltaP(SF)) in response to increased perfusion of the loop of Henle (0 to 40 nl/min) with artificial tubular fluid (ATF). The maximal TGF response was studied after 5 min of intratubular perfusion (10 nl/min) with ATF alone, or with ATF plus the A(2A) receptor antagonist (ZM-241385; 10(-7) or 10(-5) mol/l), A(1) receptor antagonist (PSB-36; 10(-8) mol/l), or with a combination of A(1) (PSB-36; 10(-8) mol/l) and A(2A) (ZM-241385; 10(-7) mol/l) antagonists. The maximal TGF response (DeltaP(SF)) with ATF alone was 11.7 +/- 1.0 mmHg. Specific A(2) inhibition (low dose) enhanced the maximal TGF response (15.7 +/- 0.8 mmHg; P < 0.01), whereas a high dose (unspecific inhibition) attenuated the response (5.0 +/- 0.4 mmHg; P < 0.001). A(1) inhibition alone led to a paradoxical TGF response, with an increase in P(SF) of 3.1 +/- 0.5 mmHg (P < 0.05). Simultaneous application of A(1) and A(2) antagonists abolished the TGF response (DeltaP(SF): 0.4 +/- 0.3 mmHg). In conclusion, adenosine A(2) receptors modulate the TGF response by counteracting the effects of adenosine A(1) receptors.
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