ArticleThe Journal of physiology2010
Atrial natriuretic peptide inhibits angiotensin II-stimulated proliferation in fetal cardiomyocytes.
Article in The Journal of physiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 40 citations in OpenAlex.
- Atrial Natriuretic Peptide Regulates Zona Glomerulosa Growth and Aldosterone Release.Hypertension (Dallas, Tex. : 1979) · 2026Article
- Lipid exposure leads to metabolic dysfunction in fetal sheep cardiomyocytes.Physiological reports · 2025Article
- Sensitivity and activation of endoplasmic reticulum stress response and apoptosis in the perinatal sheep heart.American journal of physiology. Heart and circulatory physiology · 2024Article
- Thyroid hormone increases fatty acid use in fetal ovine cardiac myocytes.Physiological reports · 2023Article
- A change of heart: understanding the mechanisms regulating cardiac proliferation and metabolism before and after birth.The Journal of physiology · 2023Review
- Natriuretic peptides and Forkhead O transcription factors act in a cooperative manner to promote cardiomyocyte cell cycle re-entry in the postnatal mouse heart.BMC developmental biology · 2021Article
- Sex differences and the effects of intrauterine hypoxia on growth and in vivo heart function of fetal guinea pigs.American journal of physiology. Regulatory, integrative and comparative physiology · 2020Article
- Right ventricular remodeling in response to volume overload in fetal sheep.American journal of physiology. Heart and circulatory physiology · 2019Article
- Thyroid hormone receptor function in maturing ovine cardiomyocytes.The Journal of physiology · 2019Article
- A Transcriptomic Model of Postnatal Cardiac Effects of Prenatal Maternal Cortisol Excess in Sheep.Frontiers in physiology · 2019Article
- Cardiomyokines from the heart.Cellular and molecular life sciences : CMLS · 2018Review
- Endocrine and other physiologic modulators of perinatal cardiomyocyte endowment.The Journal of endocrinology · 2016Review
- Systemic, but not cardiomyocyte-specific, deletion of the natriuretic peptide receptor guanylyl cyclase A increases cardiomyocyte number in neonatal mice.Histochemistry and cell biology · 2015Article
- The programming of cardiovascular disease.Journal of developmental origins of health and disease · 2015Review
- Impact of maternal obesity on fetal programming of cardiovascular disease.Physiology (Bethesda, Md.) · 2015Review
- Unexpected maturation of PI3K and MAPK-ERK signaling in fetal ovine cardiomyocytes.American journal of physiology. Heart and circulatory physiology · 2014Article
- Binucleation of cardiomyocytes: the transition from a proliferative to a terminally differentiated state.Drug discovery today · 2014Review
- How to build a healthy heart from scratch.Advances in experimental medicine and biology · 2014Review
- Differential activation of natriuretic peptide receptors modulates cardiomyocyte proliferation during development.Development (Cambridge, England) · 2014Article
- Suppression of atrial natriuretic peptide/natriuretic peptide receptor-A-mediated signaling upregulates angiotensin-II-induced collagen synthesis in adult cardiac fibroblasts.Molecular and cellular biochemistry · 2013Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The role of atrial natriuretic peptide (ANP) in regulating fetal cardiac growth is poorly understood. Angiotensin II (Ang II) stimulates proliferation in fetal sheep cardiomyocytes when growth is dependent on the activity of the mitogen-activated protein kinase (MAPK) and phosphoinositol-3-kinase (PI3K) pathways. We hypothesized that ANP would suppress near-term fetal cardiomyocyte proliferation in vitro and inhibit both the MAPK and PI3K pathways. Forty-eight hour 5-bromodeoxyuridine (BrdU) uptake (used as an index of proliferation) was measured in cardiomyocytes isolated from fetal sheep (135 day gestational age) in response to 100 nm Ang II with or without ANP (0.003-100 nm) or 1 microm 8-bromo-cGMP. The effects of these compounds on the MAPK and PI3K pathways were assessed by measuring extracellular signal-regulated kinase (ERK) and AKT phosphorylation following 10 min of treatment with Ang II, ANP or 8-bromo-cGMP. In right ventricular myocytes (RV), the lowest dose of ANP (0.003 nm) inhibited Ang II-stimulated BrdU uptake by 68%. Similarly, 8-bromo-cGMP suppressed Ang II-stimulated proliferation by 62%. The same effects were observed in left ventricular (LV) cardiomyocytes but the RV was more sensitive to the inhibitory effects of ANP than the LV (P < 0.0001). Intracellular cGMP was increased by 4-fold in the presence of 100 nm ANP. Ang II-stimulated ERK and Akt phosphorylation was inhibited by 100 nm ANP. The activity of ANP may in part be cGMP dependent, as 8-bromo-cGMP had similar effects on the cardiomyocytes.
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Registered trials
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