ArticleThe Journal of physiology2010
Sprouting capacity of lumbar motoneurons in normal and hemisected spinal cords of the rat.
Article in The Journal of physiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Optimizing neurorrhaphy to improve sensation in phalloplasty: a systematic review.International journal of impotence research · 2026Pooled it
- Improving localization and measurements of M-waves using high-density surface electromyography.Journal of neurophysiology · 2025Article
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- Selective Tibial Neurotomy for Spastic Equinovarus Foot: Operative Technique.Operative neurosurgery (Hagerstown, Md.) · 2023Article
- Donor and Recipient Nerve Axon Counts in Gender-affirming Radial Forearm Phalloplasty: Informing Choice of Nerve Coaptations.Plastic and reconstructive surgery. Global open · 2023Article
- Acellular Nerve Allografts in Major Peripheral Nerve Repairs: An Analysis of Cases Presenting With Limited Recovery.Hand (New York, N.Y.) · 2023Article
- Quantitative ultrasound imaging of intrinsic hand muscles after traumatic cervical spinal cord injury.Spinal cord · 2022Article
- Peripheral Nerve Healing: So Near and Yet So Far.Seminars in plastic surgery · 2021Review
- Peripheral Nerve Regeneration and Muscle Reinnervation.International journal of molecular sciences · 2020Review
- GDNF Gene Therapy to Repair the Injured Peripheral Nerve.Frontiers in bioengineering and biotechnology · 2020Review
- Mechanisms of compensatory plasticity for respiratory motor neuron death.Respiratory physiology & neurobiology · 2019Review
- Reinnervated muscle fiber type-grouping-inevitable?Oncotarget · 2017Article
- Differential roles of α-, β-, and γ-actin in axon growth and collateral branch formation in motoneurons.The Journal of cell biology · 2017Article
- Compensatory axon sprouting for very slow axonal die-back in a transgenic model of spinal muscular atrophy type III.The Journal of physiology · 2017Article
- The basis for diminished functional recovery after delayed peripheral nerve repair.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nerve sprouting to reinnervate partially denervated muscles is important in several disease and injury states. To examine the effectiveness of sprouting of active and inactive motor units (MUs) and the basis for a limit to sprouting, one of three rat lumbar spinal roots was cut under normal conditions and when the spinal cord was hemisected at T12. Muscle and MU isometric contractile forces were recorded and muscle fibres in glycogen-depleted single muscle units enumerated 23 to 380 days after surgery. Enlargement of intact MUs by sprouting was effective in compensating for up to 80% loss of innervation. For injuries that removed >70-80% of the intact MUs, muscle contractile force and weight dropped sharply. For partial denervation of <70%, all MUs increased contractile force by the same factor in both normally active muscles and muscles whose activity was reduced by T12 hemisection. Direct measurements of MU size by counting glycogen-depleted muscle fibres in physiologically and histochemically defined muscle units, provided direct evidence for a limit in MU size, whether or not the activity of the muscles was reduced by spinal cord hemisection. Analysis of spatial distribution of muscle fibres within the outer boundaries of the muscle unit demonstrated a progressive increase in fibres within the territory to the limit of sprouting when most of the muscle unit fibres were adjacent to each other. We conclude that the upper limit of MU enlargement may be explained by the reinnervation of denervated muscle fibres by axon sprouts within the spatial territory of the muscle unit, formerly distributed in a mosaic pattern.
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