SynthesisEpidemiologic reviews2010
Randomized controlled trials of interventions to prevent sexually transmitted infections: learning from the past to plan for the future.
Synthesis in Epidemiologic reviews, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 44 citations in OpenAlex.
- Prevention of sexually transmitted infections in urban communities (Peru PREVEN): a multicomponent community-randomised controlled trial.Lancet (London, England) · 2012Trial
- Effect of treatment assignment on intravaginal cleansing in a randomized study of the diaphragm with candidate microbicide.Journal of women's health (2002) · 2011Trial
- Effect of Screening and Treatment for Gonorrhea and Chlamydia on HIV Incidence Among Men Who Have Sex With Men in the United States: A Modeling Analysis.Sexually transmitted diseases · 2022Article
- Brazilian Protocol for Sexually Transmitted Infections, 2020: infections that cause cervicitis.Revista da Sociedade Brasileira de Medicina Tropical · 2021Article
- Sexually transmitted infections and HIV in the era of antiretroviral treatment and prevention: the biologic basis for epidemiologic synergy.Journal of the International AIDS Society · 2019Review
- Institutional context and VCT practitioner narratives: possibilities and limitations for HIV prevention in Rio de Janeiro, Brazil.BMC international health and human rights · 2017Article
- Challenges and Persistent Questions in the Treatment of Trichomoniasis.Current topics in medicinal chemistry · 2017Review
- Partner Services in Sexually Transmitted Disease Prevention Programs: A Review.Sexually transmitted diseases · 2016Review
- Bottlenecks in HIV-1 transmission: insights from the study of founder viruses.Nature reviews. Microbiology · 2015Review
- Public health interventions to control syphilis.Sexual health · 2015Article
- Toward global prevention of sexually transmitted infections (STIs): the need for STI vaccines.Vaccine · 2014Article
- Combination prevention: new hope for stopping the epidemic.Current HIV/AIDS reports · 2013Review
- Sexually Transmitted Infection (STI) screening, case and contact treatment, and condom promotion resulting in STI reduction two years later in rural Malawi.Malawi medical journal : the journal of Medical Association of Malawi · 2012Article
- Utility and delivery of behavioural interventions to prevent sexually transmitted infections.Sexually transmitted infections · 2011Article
- Pre-exposure prophylaxis state of the science: empirical analogies for research and implementation.Current HIV/AIDS reports · 2010Review
- Epidemiologic approaches to global health.Epidemiologic reviews · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Globally, sexually transmitted infections (STIs) represent a significant source of morbidity and disproportionately impact the health of women and children. The number of randomized controlled trials testing interventions to prevent STIs has dramatically increased over time. To assess their impact, the authors conducted a systematic review of interventions to prevent sexual transmission or acquisition of STIs other than human immunodeficiency virus, published in the English-language, peer-reviewed literature through December 2009. Ninety-three papers reporting data from 74 randomized controlled trials evaluating 75 STI prevention interventions were identified. Eight intervention modalities were used: behavioral interventions (36% of interventions), vaginal microbicides (16%), vaccines (16%), treatment (11%), partner services (9%), physical barriers (5%), male circumcision (5%), and multicomponent (1%). Overall, 59% of interventions demonstrated efficacy in preventing infection with at least 1 STI. Treatment interventions and vaccines for viral STIs showed the most consistently positive effects. Male circumcision protected against viral STIs and possibly trichomoniasis. Almost two-thirds of behavioral interventions were effective, but the magnitude of effects ranged broadly. Partner services yielded similarly mixed results. In contrast, vaginal microbicides and physical barrier methods demonstrated few positive effects. Future STI prevention efforts should focus on enhancing adherence within interventions, integrating new technologies, ensuring sustainable behavior change, and conducting implementation research.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.