ArticleNephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association2010
Race differences in prevalence of chronic kidney disease among young adults using creatinine-based glomerular filtration rate-estimating equations.
Article in Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 3 of them syntheses that pooled it.
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Who cites it
24 citing papers in PubMed, 3 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- Pooled it
- Health Disparities in Kidney Transplantation for African Americans.American journal of nephrology · 2017Pooled it
- Pooled it
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- Feedback Loop Failure Modes in Medical Diagnosis: How Biases Can Emerge and Be Reinforced.Medical decision making : an international journal of the Society for Medical Decision Making · 2024Article
- Review
- Patients' Perspectives on Race and the Use of Race-Based Algorithms in Clinical Decision-Making: a Qualitative Study.Journal of general internal medicine · 2023Article
- Health inequities and the inappropriate use of race in nephrology.Nature reviews. Nephrology · 2022Review
- Effect of Normalizing eGFR to Standard Body Surface Area on Rates of Obesity-Related Hyperfiltration among Diverse Female Adolescents.American journal of nephrology · 2022Article
- Genetic susceptibility of hypertension-induced kidney disease.Physiological reports · 2021Review
- Article
- Krüppel-like Factor 15: A Potential Therapeutic Target For Kidney Disease.International journal of biological sciences · 2019Review
- Black-White Difference in the Impact of Long-Term Blood Pressure From Childhood on Adult Renal Function: The Bogalusa Heart Study.American journal of hypertension · 2018Article
- Observational
- Risk of End-Stage Renal Disease in HIV-Positive Potential Live Kidney Donors.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2017Article
- Current State and Future Trends to Optimize the Care of Chronic Kidney Disease in African Americans.American journal of nephrology · 2017Article
- Racial Disparities in Creatinine-based Kidney Function Estimates Among HIV-infected Adults.Ethnicity & disease · 2016Article
- Quantification of excretory renal function and urinary protein excretion by determination of body cell mass using bioimpedance analysis.BMC nephrology · 2015Article
- Neighborhood socioeconomic status, race, and mortality in young adult dialysis patients.Journal of the American Society of Nephrology : JASN · 2014Article
- The applicability of eGFR equations to different populations.Nature reviews. Nephrology · 2013Review
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7 authors at 6 institutions in 1 country.
Funding
Abstract
backgroundDespite a higher incidence of end-stage renal disease (stage 5), blacks have been shown to have the same or lower prevalence of chronic kidney disease (CKD stages 3 and 4). Current creatinine-based glomerular filtration rate (GFR)-estimating equations may misclassify young, healthy blacks.
methodsAmong 3501 young adults (mean age 45), we compared the prevalence of CKD in blacks and whites using the Modification of Diet in Renal Disease (MDRD) and the CKD Epidemiology Collaboration (CKD-EPI) equations. In addition, we used measured creatinine excretion rates to determine the actual excretion ratio for CARDIA (race coefficient 12%) and applied this to the CKD-EPI equation. We also studied the prevalence of CKD risk factors among black and white participants near the CKD threshold cut-off (eGFR CKD-EPI 60-80 mL/min/1.73 m(2)) to estimate the relative likelihood of misclassification in blacks and whites.
resultsUsing the MDRD equation, prevalence of CKD stages 4 and 5 was higher for blacks compared with whites (0.6% vs. 0.1%, P-value 0.05). In contrast, prevalence of eGFR <60 mL/min/1.73 m(2) was significantly higher for whites (3.6%) compared with blacks (1.9%), due to higher prevalence of stage 3 among whites. Prevalence of CKD was similar for blacks and whites using CKD-EPI equation (1.2%), but was higher among blacks when using the CARDIA-derived race coefficient (1.6% vs.1.2%, P-value = 0.03). Among persons with eGFR by CKD-EPI of 60-80 mL/min/1.73 m(2), blacks had higher levels of albuminuria, uric acid, systolic blood pressure and higher diabetes prevalence.
conclusionsCKD classification among young blacks is very sensitive to the race coefficients. Despite whites having higher rates of CKD stage 3, blacks with eGFRs just above the CKD threshold had higher rates of CKD risk factors. Current equations used to define CKD may systematically miss a high-risk group of blacks at a time in the disease course when interventions are crucial.
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