ReviewExpert review of vaccines2010
The challenge of assessing infant vaccine responses in resource-poor settings.
Review in Expert review of vaccines, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed.
- Efficacy, public health impact and optimal use of the Takeda dengue vaccine.Nature medicine · 2025Article
- Gathering information on maternal immunization readiness in Bangladesh, Ghana, Kenya, Mozambique, and Nepal: Applying a WHO checklist.Human vaccines & immunotherapeutics · 2024Article
- Sustained antigen delivery improves germinal center reaction and increases antibody responses in neonatal mice.NPJ vaccines · 2024Article
- Development of a live attenuated trivalent porcine rotavirus A vaccine against disease caused by recent strains most prevalent in South Korea.Veterinary research · 2019Article
- IL-6 Impairs Vaccine Responses in Neonatal Mice.Frontiers in immunology · 2018Article
- Single-cell analysis of innate cytokine responses to pattern recognition receptor stimulation in children across four continents.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Ontogeny of early life immunity.Trends in immunology · 2014Review
- Pattern recognition receptor-mediated cytokine response in infants across 4 continents.The Journal of allergy and clinical immunology · 2014Article
- Ontogeny of Toll-like receptor mediated cytokine responses of South African infants throughout the first year of life.PloS one · 2012Article
- Methods to measure vaccine immunity.Expert review of vaccines · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Newborns and infants are highly susceptible to infectious diseases, resulting in high mortality and morbidity, particularly in resource-poor settings. Many vaccines require several booster doses, resulting in an extensive vaccine schedule, and yet there is still inadequate protection from some of these diseases. This is partly due to the immaturity of the neonate and infant immune system. Little is known about the specific modifications to immunological assessment protocols in early life but increasing knowledge of infant immunology has helped provide better recommendations for assessing these responses. Since most new vaccines will eventually be deployed in low-income settings such as Africa, the logistics and resources of assessing immunity in such settings also need to be understood. In this article, we will review immunity to vaccines in early life, discuss the many challenges associated with assessing immunogenicity and provide practical tips.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.