ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2010
Association analysis of GSTT1, GSTM1 genotype polymorphisms and serum total GST activity with ischemic stroke risk.
Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 5 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 5 syntheses or guidelines pooled it, 43 citations in OpenAlex.
- An updated meta-analysis showed smoking modify the association of GSTM1 null genotype on the risk of coronary heart disease.Bioscience reports · 2021Pooled it
- Glutathione S-Transferase M1 and T1 polymorphisms and hypertension risk: an updated meta-analysis.Journal of human hypertension · 2019Pooled it
- Glutathione S-transferase M1 (GSTM1) and T1 (GSTT1) null polymorphisms and the risk of hypertension: a meta-analysis.PloS one · 2015Pooled it
- Glutathione-S-transferase M1 and T1 null genotypes are associated with hypertension risk: a systematic review and meta-analysis of 12 studies.Current hypertension reports · 2014Pooled it
- GSTT1 null genotype contributes to coronary heart disease risk: a meta-analysis.Molecular biology reports · 2012Pooled it
- Association of genotypes at single-nucleotide polymorphisms inIBRO neuroscience reports · 2025Article
- The role of glutathione S-transferases in human disease pathogenesis and their current inhibitors.Genes & diseases · 2025Review
- The Impact of Genetic Polymorphisms in Glutamate-Cysteine Ligase, a Key Enzyme of Glutathione Biosynthesis, on Ischemic Stroke Risk and Brain Infarct Size.Life (Basel, Switzerland) · 2022Article
- GSTM1 Modulates Expression of Endothelial Adhesion Molecules in Uremic Milieu.Oxidative medicine and cellular longevity · 2021Article
- Article
- Glutathione S-transferase P1 gene polymorphisms and susceptibility to coronary artery disease in a subgroup of north Indian population.Journal of genetics · 2017Article
- The impact of detoxifying and repair gene polymorphisms on oxidative stress in ischemic stroke.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2016Article
- Antioxidant Potential of Vespa affinis L., a Traditional Edible Insect Species of North East India.PloS one · 2016Article
- Genetic variation in glutathione S-transferase genes and risk of nonfatal cerebral stroke in patients suffering from essential hypertension.Journal of molecular neuroscience : MN · 2012Article
- Association of glutathione S-transferase T1 and M1 gene polymorphisms with ischemic stroke risk in the Chinese Han population.Neural regeneration research · 2012Article
- Combined GSTM1 and GSTT1 null genotypes are strong risk factors for atherogenesis in a Serbian population.Genetics and molecular biologyArticle
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oxidative stress plays a major role in pathogenesis of atherosclerosis which is responsible for stroke. Glutathione S-transferases (GSTs) detoxify metabolites produced by oxidative stress within the cell and protect the cells against injury. This study aimed to investigate the association of polymorphisms in GSTT1, GSTM1 genes and GST activity with ischemic stroke risk. Patients had almost the same GST activity as that of controls. No significant differences were found between patients and controls in terms of GSTT1 null, GSTM1 null and GSTT1/GSTM1 double null genotype frequencies. Besides, both patients and controls with double GSTT1/GSTM1 null genotypes had the lowest serum GST activities. Compared to the present genotypes, GSTT1 null (OR = 4.888; P = 0.006) and GSTM1 null (OR = 2.383; P = 0.011) genotype groups contained relatively more hypertensive stroke patients. This study showed that GSTT1 and GSTM1 null genotypes, together with hypertension, may play a significant role in the pathogenesis of ischemic stroke.
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