ArticleWiener klinische Wochenschrift2010
Autoantibodies pANCA, GAB and PAB in inflammatory bowel disease: prevalence, characteristics and diagnostic value.
Article in Wiener klinische Wochenschrift, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 29 citations in OpenAlex.
- Mechanisms of Inflammation in Post-Operative Recurrence of Crohn's Disease.Journal of inflammation research · 2026Review
- Rare Oral Crohn's Disease: A Case Report.Cureus · 2023Article
- Anti-Saccharomyces cerevisiae Antibodies Are Only Modestly More Common in Subjects Later Developing Crohn's Disease.Digestive diseases and sciences · 2023Article
- Age and Gender: Affecting the Positive Rates of Serum PAB and ANCA in Patients with Inflammatory Bowel Disease.Gastroenterology research and practice · 2021Article
- Identification of Chitinase-3-Like Protein 1 as a Novel Neutrophil Antigenic Target in Crohn's Disease.Journal of Crohn's & colitis · 2019Article
- Anti-neutrophil cytoplasmic antibodies and their clinical significance.Clinical rheumatology · 2018Review
- PR3-ANCA and panel diagnostics in pediatric inflammatory bowel disease to distinguish ulcerative colitis from Crohn's disease.PloS one · 2018Article
- A Potential Role ofFrontiers in immunology · 2017Review
- Inflammatory bowel disease and celiac disease: overlaps and differences.World journal of gastroenterology · 2014Review
- Serological markers of inflammatory bowel disease.Biochemia medica · 2013Review
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe diagnosis of inflammatory bowel disease (IBD), particularly the differentiation between ulcerative colitis (UC) and Crohn's disease (CD), is difficult and delayed in many cases, despite invasive diagnostic tools.
aimsTo determine the presence and evaluate the diagnostic accuracy of the potential serological diagnostic markers perinuclear antineutrophil cytoplasmic antibodies (pANCA), autoantibodies to intestinal goblet cells (GAB) and autoantibodies to exocrine pancreas (PAB), together with combinations of these, in the diagnosis of IBD and differential diagnosis of UC and CD.
methodsThe presence of pANCA, GAB and PAB was determined in indirect immunofluorescence assay of serum samples from 71 patients with IBD (CD 43, UC 28) and 41 healthy controls. The antigen specificity of ANCA was determined using ELISA.
resultsCompared with the control group, we confirmed a statistically significant presence of pANCA (71.4%) and GAB (46.4%) in patients with UC and the presence of PAB only in patients with CD (30.2%) (P < 0.001). In healthy controls, neither PAB nor GAB was detected and pANCA was present in only 4.8%. The sensitivity, specificity and positive and negative predictive values in differentiation of IBD from healthy controls were as follows: pANCA(+): 71%, 95%, 91%, 83%; GAB(+): 46%, 100%, 100%, 73%; PAB(+): 30%, 100%, 100%, 58%; combination of (pANCA(+) or GAB(+))/PAB(-): 82%, 95%, 92%, 87%; and to distinguish UC from CD: pANCA(+): 71%, 98%, 95%, 84%; GAB(+): 46%, 98%, 93%, 74%; PAB(+): 30%, 100%, 100%, 48%; (pANCA(+) or GAB(+))/PAB(-): 82%, 98%, 96%, 89%.
conclusionsAll three autoantibodies may be helpful tools in non-invasive diagnosis and differential diagnosis of UC and CD. Combination of the autoantibodies may be particularly helpful, as the diagnostic sensitivity is considerably improved.
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