ReviewNature reviews. Nephrology2010
Drug-induced acute interstitial nephritis.
Review in Nature reviews. Nephrology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 146 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
146 citing papers in PubMed, 1 synthesis or guideline pooled it, 366 citations in OpenAlex.
- Tubulointerstitial nephritis and uveitis (TINU) syndrome: a systematic review of its epidemiology, demographics and risk factors.Orphanet journal of rare diseases · 2017Pooled it
- Delayed Drug Hypersensitivity: Mechanistic Advances and Emerging Therapies.Current allergy and asthma reports · 2026Review
- Acute tubular injury versus acute interstitial nephritis in the kidney precision medicine project.JCI insight · 2026Observational
- Therapeutic and mechanistic insights on mitochondrial transplantation in kidney disease.Nature reviews. Nephrology · 2026Review
- Acute Interstitial Nephritis Is a Potential Adverse Effect in Inflammatory Bowel Disease Patients Treated With Vedolizumab: A Case Report and Review of the Literature.Kidney medicine · 2026Article
- Stress-Dependent NF-κB Signaling in Acute Kidney Injury: Linking Inflammation, Autophagy, and Apoptosis.International journal of molecular sciences · 2026Review
- Significant kidney impairment in pediatric inflammatory bowel disease and practice points for pediatric gastroenterologists.Journal of pediatric gastroenterology and nutrition · 2026Observational
- Acute interstitial nephritis due to acute pyelonephritis in a young woman: diagnostic utility of CK7 and CD10 immunostaining.CEN case reports · 2026Article
- Renal involvement in ankylosing spondylitis: a retrospective, population-based cohort study using data from the TriNetX Global Network.RMD open · 2026Article
- Age-Adjusted Mortality Trends in Acute Tubulointerstitial Nephritis by Gender, Race, and Census Region in the United States: A CDC-WONDER Study, 1999-2020.Journal of clinical medicine · 2026Article
- Urinary CD4Scientific reports · 2026Article
- Acute Kidney Injury Following Duloxetine (Cymbalta) Therapy in a 43-Year-Old Female: A Case Report.Cureus · 2026Article
- Case Report: Autoimmune-associated tubulointerstitial nephritis with predominant Sjögren features in a child presenting with recurrent sterile pyuria.Frontiers in pediatrics · 2026Article
- Always Consider a Repeat Kidney Biopsy: Acute Interstitial Nephritis Soon After Membranous Nephropathy.Case reports in nephrology · 2026Article
- Toxins and the Kidneys: A Two-Way Street.Toxins · 2025Review
- A new category for understanding the mechanisms of drug-induced kidney injury.Renal failure · 2025Review
- Abemaciclib-associated acute interstitial nephritis successfully treated with glucocorticoids: a case report and literature review.BMC nephrology · 2025Review
- Antimicrobial Prophylaxis in Elective Orthopaedic Surgical Procedures at the Tertiary Care Hospital: A Prospective Observational Study.Antibiotics (Basel, Switzerland) · 2025Article
- Successful Resolution of Suspected Red Yeast Rice-induced Nephropathy.Internal medicine (Tokyo, Japan) · 2025Article
- Article
86 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acute interstitial nephritis (AIN) is a common cause of acute kidney injury. Many etiologies of AIN have been recognized--including allergic/drug-induced, infectious, autoimmune/systemic, and idiopathic forms of disease. The most common etiology of AIN is drug-induced disease, which is thought to underlie 60-70% of cases. Multiple agents from many different classes of drugs can cause AIN, and the clinical presentation and laboratory findings vary according to the class of drug involved. AIN is characterized by interstitial inflammation, tubulitis, edema, and in some cases, eventual interstitial fibrosis. A definitive diagnosis of AIN can be established only by kidney biopsy. Noninvasive tests such as (67)gallium scintigraphy and testing for eosinophiluria have limited diagnostic utility. The mainstay of therapy for drug-induced AIN is timely discontinuation of the causative agent. Although the benefits of corticosteroid therapy remain unproven, they do appear to have a positive effect in some patients with drug-induced AIN, especially when treatment is initiated early in the course of the disease. In general, the prognosis for drug-induced AIN is good, and at least partial recovery of kidney function is normally observed. Early recognition is crucial because patients can ultimately develop chronic kidney disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.