ArticleCells, tissues, organs2010
Morphological and extracellular matrix changes following vocal fold injury in mice.
Article in Cells, tissues, organs, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed.
- Identification of stem cell marker-positive subpopulations in the vocal fold of the larynx through transcriptomic analyses.Nature communications · 2026Article
- Mouse Vocal Fold Permeability In Vivo: Effects of Novel Low-Tech Injury and Instillation Methods.The Laryngoscope · 2026Article
- Establishing a Mouse Model of Surgical Vocal Fold Injury.The Laryngoscope · 2025Article
- Matrix Adhesiveness Regulates Myofibroblast Differentiation from Vocal Fold Fibroblasts in a Bio-orthogonally Cross-linked Hydrogel.ACS applied materials & interfaces · 2022Article
- Exposure to e-cigarette vapor extract induces vocal fold epithelial injury and triggers intense mucosal remodeling.Disease models & mechanisms · 2022Article
- Expanded Basal Compartment and Disrupted Barrier in Vocal Fold Epithelium Infected with Mouse Papillomavirus MmuPV1.Viruses · 2022Article
- Article
- Experimental model for controlled endoscopic subepithelial vocal fold injury in rats.Acta cirurgica brasileira · 2022Article
- Induction of Fibrogenic Phenotype in Human Mesenchymal Stem Cells by Connective Tissue Growth Factor in a Hydrogel Model of Soft Connective Tissue.ACS biomaterials science & engineering · 2019Article
- Pathophysiology of Fibrosis in the Vocal Fold: Current Research, Future Treatment Strategies, and Obstacles to Restoring Vocal Fold Pliability.International journal of molecular sciences · 2019Review
- Laryngeal airway reconstruction indicates that rodent ultrasonic vocalizations are produced by an edge-tone mechanism.Royal Society open science · 2017Article
- Insights Into the Role of Collagen in Vocal Fold Health and Disease.Journal of voice : official journal of the Voice Foundation · 2017Review
- Grasshopper mice employ distinct vocal production mechanisms in different social contexts.Proceedings. Biological sciences · 2017Article
- A Review of Hyaluronic Acid and Hyaluronic Acid-based Hydrogels for Vocal Fold Tissue Engineering.Journal of voice : official journal of the Voice Foundation · 2017Review
- Dexamethasone Controlled Release on TGF-β1 Treated Vocal Fold Fibroblasts.The Annals of otology, rhinology, and laryngology · 2015Article
- Classification for animal vocal fold surgery: resection margins impact histological outcomes of vocal fold injury.The Laryngoscope · 2014Article
- Age effects on extracellular matrix production of vocal fold scar fibroblasts in rats.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2014Article
- TGF-β3 modulates the inflammatory environment and reduces scar formation following vocal fold mucosal injury in rats.Disease models & mechanisms · 2014Article
- Regulation of wound healing by granulocyte-macrophage colony-stimulating factor after vocal fold injury.PloS one · 2013Article
- Elastic fiber-mediated enthesis in the human middle ear.Journal of anatomy · 2012Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Mouse experimental models are commonly utilized tools in biomedical research but remain underrepresented in vocal fold biology, presumably due to the small size of the larynx and limited description of the anatomical, cellular and extracellular composition of the vocal folds. In this study, we provide a whole-mount serial section-based histological description of vocal fold morphology of wild-type FVB strain mice, alongside a histological and immunohistochemical (IHC)-based quantitative analysis of extracellular matrix (ECM) alteration 1, 7, 14, 28, 42 and 56 days following unilateral vocal fold injury. IHC was specific for procollagen type I, collagen type I, collagen type III, collagen type IV, elastin, decorin, fibronectin and hyaluronic acid binding protein 2. The histological description confirmed the presence of a laryngeal alar structural complex in the mouse, which appears to be a morphological feature unique to rodents. The lamina propria appeared uniform without evidence of a distinct layer structure as has been reported in larger animals and humans. Time-dependent alterations in vocal fold morphology, ECM organization and ECM protein/glycoconjugate abundance were observed in injured vocal folds compared to control. The presence of a mature scar was observed between 28 and 42 days postinjury. Morphological and ECM changes following vocal fold injury in the mouse were generally consistent with those reported in other animal models, particularly the rat, although wound repair in the mouse appears to occur at a faster rate.
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