ArticleAntimicrobial agents and chemotherapy2010
Contribution of a plasmid-borne blaOXA-58 gene with its hybrid promoter provided by IS1006 and an ISAba3-like element to beta-lactam resistance in acinetobacter genomic species 13TU.
Article in Antimicrobial agents and chemotherapy, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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31 citing papers in PubMed, 48 citations in OpenAlex.
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- Genetic Characterization of Carbapenem-ResistantAntibiotics (Basel, Switzerland) · 2026Article
- The deficiency of poly-β-1,6-N-acetyl-glucosamine deacetylase trigger A. baumannii to convert to biofilm-independent colistin-tolerant cells.Scientific reports · 2023Article
- Structural Basis of PER-1-Mediated Cefiderocol Resistance and Synergistic Inhibition of PER-1 by Cefiderocol in Combination with Avibactam or Durlobactam in Acinetobacter baumannii.Antimicrobial agents and chemotherapy · 2022Article
- Resistance traits and molecular characterization of multidrug-resistant Acinetobacter baumannii isolates from an intensive care unit of a tertiary hospital in Guangdong, southern China.International microbiology : the official journal of the Spanish Society for Microbiology · 2022Article
- How Do Transposable Elements Activate Expression of Transcriptionally Silent Antibiotic Resistance Genes?International journal of molecular sciences · 2022Review
- Global Threat of Carbapenem-Resistant Gram-Negative Bacteria.Frontiers in cellular and infection microbiology · 2022Review
- Genomic characterization of triple-carbapenemase-producingJAC-antimicrobial resistance · 2021Article
- Profile of Enterobacteria Resistant to Beta-Lactams.Antibiotics (Basel, Switzerland) · 2020Article
- Epidemiology, Treatment, and Prevention of Nosocomial Bacterial Pneumonia.Journal of clinical medicine · 2020Review
- Prevalence and Characterization of Carbapenem-Hydrolyzing Class D β-Lactamase-ProducingFrontiers in microbiology · 2020Article
- Carbapenemase Genes and Multidrug Resistance ofAntibiotics (Basel, Switzerland) · 2019Article
- Molecular Epidemiology of Emerging Carbapenem Resistance inAntimicrobial agents and chemotherapy · 2019Article
- Detection of co-harboring OXA-58 and NDM-1 carbapenemase producing genes resided on a same plasmid from anIranian journal of basic medical sciences · 2019Article
- Biofilm formation is not associated with worse outcome in Acinetobacter baumannii bacteraemic pneumonia.Scientific reports · 2018Article
- Multicenter Study of Clinical Features of Breakthrough Acinetobacter Bacteremia during Carbapenem Therapy.Antimicrobial agents and chemotherapy · 2017Article
- Multicenter Study of the Relationship between Carbapenem MIC Values and Clinical Outcome of Patients with Acinetobacter Bacteremia.Antimicrobial agents and chemotherapy · 2017Article
- High prevalence of the PER-1 gene among carbapenem-resistant Acinetobacter baumannii in Riyadh, Saudi Arabia.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2016Article
- Individual or Combined Effects of Meropenem, Imipenem, Sulbactam, Colistin, and Tigecycline on Biofilm-Embedded Acinetobacter baumannii and Biofilm Architecture.Antimicrobial agents and chemotherapy · 2016Article
- Comparative Phosphoproteomics Reveals the Role of AmpC β-lactamase Phosphorylation in the Clinical Imipenem-resistant Strain Acinetobacter baumannii SK17.Molecular & cellular proteomics : MCP · 2016Article
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8 authors at 5 institutions in 2 countries.
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No grant is acknowledged in the PubMed record.
Abstract
The contribution of the blaOXA-58 gene and its promoter to beta-lactam resistance has not been validated in Acinetobacter spp. other than Acinetobacter baumannii. We identified a multidrug-resistant (including carbapenem resistance) Acinetobacter genomic species 13TU in which blaOXA-58 was the only detected carbapenemase gene. The blaOXA-58 gene was plasmid located, flanked by ISAba3 (downstream) and an ISAba3-like element (upstream). An IS1006 element was inserted into ISAba3-like (IS1006-DeltaISAba3-like) to generate a hybrid promoter for blaOXA-58, with a -35 promoter located in IS1006 and a -10 promoter in ISAba3-like. The reference strain of Acinetobacter genomic species 13TU, ATCC 17903, revealed higher MICs of amoxicillin, ticarcillin, and piperacillin and heteroresistance to imipenem and meropenem when it was transformed with a shuttle vector containing a fragment encompassing DeltaISAba3-like-blaOXA-58, compared to the same host containing only blaOXA-58. When the fragment was changed from DeltaISAba3-like-blaOXA-58 to IS1006-DeltaISAba3-like-blaOXA-58, the ATCC 17903 transformant revealed a markedly higher level of blaOXA-58 transcription (12-fold), increased cefuroxime and piperacillin-tazobactam MICs, and homoresistance to imipenem and meropenem. Different roles of the insertion elements preceding the blaOXA-58 gene in Acinetobacter genomic species 13TU are demonstrated. The ISAba3-like--blaOXA-58 construct can mediate resistance to penicillin derivatives but only heteroresistance to carbapenems. The insertion of IS1006 into ISAba3-like, generating a hybrid promoter, could further enhance the transcription of blaOXA-58 and mediate homoresistance to carbapenems and also enhanced resistance to piperacillin-tazobactam.
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