ArticleAntimicrobial agents and chemotherapy2010
Brain microdialysis study of meropenem in two patients with acute brain injury.
Article in Antimicrobial agents and chemotherapy, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The trial behind it
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Who cites it
15 citing papers in PubMed, 26 citations in OpenAlex.
- Population Pharmacokinetics and Dosing Regimen Optimization of Meropenem in Cerebrospinal Fluid and Plasma in Patients with Meningitis after Neurosurgery.Antimicrobial agents and chemotherapy · 2016Trial
- Monitoring vigabatrin in head injury patients by cerebral microdialysis: obtaining pharmacokinetic measurements in a neurocritical care setting.British journal of clinical pharmacology · 2014Trial
- Article
- An overview of clinical cerebral microdialysis in acute brain injury.Frontiers in neurology · 2023Review
- A Minimal Physiologically Based Pharmacokinetic Model to Characterize CNS Distribution of Metronidazole in Neuro Care ICU Patients.Antibiotics (Basel, Switzerland) · 2022Article
- Concentrations of Cefuroxime in Brain Tissue of Neurointensive Care Patients.Antimicrobial agents and chemotherapy · 2018Article
- Microdialysis Monitoring in Clinical Traumatic Brain Injury and Its Role in Neuroprotective Drug Development.The AAPS journal · 2017Review
- Pharmacokinetics of Colistin Methansulphonate (CMS) and Colistin after CMS Nebulisation in Baboon Monkeys.Pharmaceutical research · 2015Article
- Consensus statement from the 2014 International Microdialysis Forum.Intensive care medicine · 2015Article
- Metronidazole and hydroxymetronidazole central nervous system distribution: 1. microdialysis assessment of brain extracellular fluid concentrations in patients with acute brain injury.Antimicrobial agents and chemotherapy · 2014Article
- Metronidazole and hydroxymetronidazole central nervous system distribution: 2. cerebrospinal fluid concentration measurements in patients with external ventricular drain.Antimicrobial agents and chemotherapy · 2014Article
- Cerebral microdialysis in clinical studies of drugs: pharmacokinetic applications.Journal of pharmacokinetics and pharmacodynamics · 2013Review
- Microdialysis study of cefotaxime cerebral distribution in patients with acute brain injury.Antimicrobial agents and chemotherapy · 2013Article
- Importance of relating efficacy measures to unbound drug concentrations for anti-infective agents.Clinical microbiology reviews · 2013Review
- Modeling approach to characterize intraocular doripenem pharmacokinetics after intravenous administration to rabbits, with tentative extrapolation to humans.Antimicrobial agents and chemotherapy · 2012Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Concentrations of unbound meropenem in the cerebral extracellular fluid (ECF) of two patients with acute brain injury were assessed by microdialysis. Brain ECF unbound-meropenem concentrations were lower than serum unbound-meropenem concentrations, with brain-to-serum area under the concentration-time curve ratios of 0.73 and 0.14. A pharmacokinetic model was developed to fit the experimental data adequately.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.