ArticleCancer research2010
Calcium intake increases risk of prostate cancer among Singapore Chinese.
Article in Cancer research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 2 syntheses or guidelines pooled it, 64 citations in OpenAlex.
- Dietary calcium intake and hypertension risk: a dose-response meta-analysis of prospective cohort studies.European journal of clinical nutrition · 2019Pooled it
- Total Calcium (Dietary and Supplementary) Intake and Prostate Cancer: a Systematic Review and Meta-AnalysisAsian Pacific journal of cancer prevention : APJCP · 2018Pooled it
- Genetic Polymorphisms and Antioxidant Reactions in Prostate Cancer.International journal of molecular sciences · 2026Review
- Dairy consumption and risks of total and site-specific cancers in Chinese adults: an 11-year prospective study of 0.5 million people.BMC medicine · 2022Article
- Review
- Metabolic reprogramming in prostate cancer.British journal of cancer · 2021Review
- Differences in health status of Slovak municipalities supplied with drinking water of different hardness values.Environmental geochemistry and health · 2021Article
- Article
- Dairy, soy, and calcium consumption and risk of cognitive impairment: the Singapore Chinese Health Study.European journal of nutrition · 2020Article
- Phytochemicals in Prostate Cancer: From Bioactive Molecules to Upcoming Therapeutic Agents.Nutrients · 2019Review
- Dietary Nutrient Patterns and Prostate Cancer Risk: A Case-Control Study from IranAsian Pacific journal of cancer prevention : APJCP · 2019Article
- The incidence, mortality, and risk factors of prostate cancer in Asian men.Prostate international · 2019Review
- The Epidemiology of Prostate Cancer.Cold Spring Harbor perspectives in medicine · 2018Review
- Mendelian randomization does not support serum calcium in prostate cancer risk.Cancer causes & control : CCC · 2018Article
- Dairy intake and risk of type 2 diabetes.Clinical nutrition (Edinburgh, Scotland) · 2018Article
- Impact of Calcium and Magnesium in Groundwater and Drinking Water on the Health of Inhabitants of the Slovak Republic.International journal of environmental research and public health · 2017Article
- Dairy Food Intake Is Inversely Associated with Risk of Hypertension: The Singapore Chinese Health Study.The Journal of nutrition · 2017Article
- Chemical composition of groundwater/drinking water and oncological disease mortality in Slovak Republic.Environmental geochemistry and health · 2017Article
- Race and BMI modify associations of calcium and vitamin D intake with prostate cancer.BMC cancer · 2017Article
- Signaling regulation and role of filamin A cleavage in Ca2+-stimulated migration of androgen receptor-deficient prostate cancer cells.Oncotarget · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Consumption of dairy products, the primary source of calcium in Western diets, has been found to be positively associated with prostate cancer. In an Asian diet, nondairy foods are the major contributors of calcium. Thus, a study of dietary calcium and prostate cancer in Asians can better inform on whether calcium, as opposed to other dairy components, is responsible for the dairy foods-prostate cancer association. We examined calcium intake and prostate cancer risk among 27,293 men in the Singapore Chinese Health Study that was established between 1993 and 1998. As of December 31, 2007, 298 incident prostate cancer cases had been diagnosed among the cohort members. Diet was assessed at baseline with a validated 165-item food-frequency questionnaire. It is hypothesized that there is greater net absorption of calcium in smaller individuals. Therefore, the calcium-prostate cancer association was also assessed in stratified analyses by median body mass index. Vegetables were the largest contributor of daily calcium intake in the study population. Overall, we observed a modest, statistically nonsignificant 25% increase in prostate cancer risk for the 4th (median = 659 mg/d) versus 1st (median = 211 mg/d) quartiles of calcium intake after adjustment for potential confounders. The association became considerably stronger and achieved statistical significance (hazard ratio, 2.03; 95% confidence interval, 1.23-3.34; P for trend = 0.01) for men with a below median body mass index (22.9 kg/m(2)). Dietary calcium might be a risk factor for prostate cancer even at relatively low intake.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.