ArticleThe Journal of biological chemistry2010
myo-Inositol-1-phosphate synthase is required for polar auxin transport and organ development.
Article in The Journal of biological chemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 67 citations in OpenAlex.
- Transcriptomic analyses of piperitone inhibited sprouting of 'Yan 25' sweet potato storage roots.Food chemistry. Molecular sciences · 2026Article
- Chemical inhibition of INO1 reduces phytic acid in rice and wheat grains for enhanced micronutrient bioavailability.Nature food · 2026Article
- Phosphatidylinositides regulate the cell plate morphology transition during cytokinesis in Arabidopsis.Nature communications · 2025Article
- Enhanced auxin signaling promotes root-hair growth at moderately low temperature in Arabidopsis thaliana.Plant communications · 2025Article
- Plants distinguish different photoperiods to independently control seasonal flowering and growth.Science (New York, N.Y.) · 2024Article
- Combined Application of Myo-Inositol and Corn Steep Liquor from Agricultural Waste Alleviate Salt Stress inPlants (Basel, Switzerland) · 2023Article
- HEXOKINASE1 and glucose-6-phosphate fuel plant growth and development.Development (Cambridge, England) · 2023Article
- Parallel mechanisms detect different photoperiods to independently control seasonal flowering and growth in plants.bioRxiv : the preprint server for biology · 2023Article
- Co-culturing experiments reveal the uptake of myo-inositol phosphate synthase (EC 5.5.1.4) in an inositol auxotroph of Saccharomyces cerevisiae.Microbial cell factories · 2021Article
- Transcriptome analysis identifies differentially expressed genes in the progenies of a cross between two low phytic acid soybean mutants.Scientific reports · 2021Article
- Single-cell RNA sequencing of developing maize ears facilitates functional analysis and trait candidate gene discovery.Developmental cell · 2021Article
- Role of myo-inositol during skotomorphogenesis in Arabidopsis.Scientific reports · 2020Article
- Involvement of Arabidopsis BIG protein in cell death mediated by Myo-inositol homeostasis.Scientific reports · 2020Article
- Inositol hexakisphosphate biosynthesis underpins PAMP-triggered immunity to Pseudomonas syringae pv. tomato in Arabidopsis thaliana but is dispensable for establishment of systemic acquired resistance.Molecular plant pathology · 2020Article
- Phytic Acid and Transporters: What Can We Learn fromPlants (Basel, Switzerland) · 2020Review
- Identity and functions of inorganic and inositol polyphosphates in plants.The New phytologist · 2020Review
- Jasmonates-Mediated Rewiring of Central Metabolism Regulates Adaptive Responses.Plant & cell physiology · 2019Article
- Waterlogging tolerance rendered by oxylipin-mediated metabolic reprogramming in Arabidopsis.Journal of experimental botany · 2019Article
- A Cotton (International journal of molecular sciences · 2019Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
myo-Inositol-1-phosphate synthase is a conserved enzyme that catalyzes the first committed and rate-limiting step in inositol biosynthesis. Despite its wide occurrence in all eukaryotes, the role of myo-inositol-1-phosphate synthase and de novo inositol biosynthesis in cell signaling and organism development has been unclear. In this study, we isolated loss-of-function mutants in the Arabidopsis MIPS1 gene from different ecotypes. It was found that all null mips1 mutants are defective in embryogenesis, cotyledon venation patterning, root growth, and root cap development. The mutant roots are also agravitropic and have reduced basipetal auxin transport. mips1 mutants have significantly reduced levels of major phosphatidylinositols and exhibit much slower rates of endocytosis. Treatment with brefeldin A induces slower PIN2 protein aggregation in mips1, indicating altered PIN2 trafficking. Our results demonstrate that MIPS1 is critical for maintaining phosphatidylinositol levels and affects pattern formation in plants likely through regulation of auxin distribution.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.