Evidence map›Paper›PMID 20515930›Full record

ArticleInfection and immunity2010

Identification of Campylobacter jejuni genes involved in its interaction with epithelial cells.

Veronica Novik, Dirk Hofreuter, Jorge E Galán

Open access · greenAbstract read
In one paragraph

Article in Infection and immunity, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.

0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed
12.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

68 citing papers in PubMed, 107 citations in OpenAlex.

  1. Cross-Host Adaptation ofMicroorganisms · 2026
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  3. Impact of flagellar filament length onJournal of bacteriology · 2025
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  4. FliO is an evolutionarily conserved yet diversified core component of the bacterial flagellar type III secretion system.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  5. Genetic Factors ofPathogens (Basel, Switzerland) · 2025
    Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Campylobacter Virulence Factors and Molecular Host-Pathogen Interactions.Current topics in microbiology and immunology · 2021
    Review
  15. Article
  16. Article
  17. Article
  18. Agricultural intensification and the evolution of host specialism in the enteric pathogenProceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  19. Taking Control:Frontiers in microbiology · 2020
    Review
  20. RevisitingFrontiers in cellular and infection microbiology · 2020
    Review

8 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Veronica NovikSection of Microbial Pathogenesis, Yale University School of Medicine, Boyer Center for Molecular Medicine, 295 Congress Ave., New Haven, CT 06536, USA.
Dirk Hofreuter
Jorge E Galán
Yale University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Campylobacter jejuni is the leading cause of infectious gastroenteritis in industrialized nations. Its ability to enter and survive within nonphagocytic cells is thought to be very important for pathogenesis. However, little is known about the C. jejuni determinants that mediate these processes. Through an extensive transposon mutagenesis screen, we have identified several loci that are required for C. jejuni efficient entry and survival within epithelial cells. Among these loci, insertional mutations in aspA, aspB, and sodB resulted in drastic reduction in C. jejuni entry and/or survival within host cells and a severe defect in colonization in an animal model. The implications of these findings for the understanding of C. jejuni-host cell interactions are discussed.

Indexed as

Bacterial AdhesionAnimalsBacterial ProteinsCampylobacter InfectionsCampylobacter jejuniCell LineChlorocebus aethiopsColony Count, MicrobialCytoplasmDNA Transposable ElementsEpithelial CellsFecesGene Knockout TechniquesHumansMaleMiceBacterial ProteinsDNA Transposable ElementsVirulence Factors

Identifiers

PMID20515930
PMCPMC2916286
OpenAlexW2160148244

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.