ArticleInfection and immunity2010
Absence of poly(ADP-ribose) polymerase 1 delays the onset of Salmonella enterica serovar Typhimurium-induced gut inflammation.
Article in Infection and immunity, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 33 citations in OpenAlex.
- 18β-Glycyrrhetinic Acid AttenuatesAnimals : an open access journal from MDPI · 2026Article
- Covalent Probes To CaptureJournal of the American Chemical Society · 2024Article
- Protective effects of 18β-glycyrrhetinic acid onFrontiers in veterinary science · 2024Article
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- 18β-Glycyrrhetinic Acid AlleviatesInfection and drug resistance · 2023Article
- NADTrends in immunology · 2022Review
- Stabilization but No Functional Influence of HIF-1α Expression in the Intestinal Epithelium during Salmonella Typhimurium Infection.Infection and immunity · 2022Article
- PARP-1-Associated Pathological Processes: Inhibition by Natural Polyphenols.International journal of molecular sciences · 2021Review
- Intestinal Infection Is Associated With Impaired Lung Innate Immunity to Secondary Respiratory Infection.Open forum infectious diseases · 2021Article
- Inflammation-induced DNA damage, mutations and cancer.DNA repair · 2019Review
- Pten gene deletion in intestinal epithelial cells enhances susceptibility to Salmonella Typhimurium infection in mice.Journal of microbiology (Seoul, Korea) · 2019Article
- Poly(ADP-Ribose) Polymerases in Host-Pathogen Interactions, Inflammation, and Immunity.Microbiology and molecular biology reviews : MMBR · 2019Review
- PARP-1 protects against colorectal tumor induction, but promotes inflammation-driven colorectal tumor progression.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Inherited DNA lesions determine G1 duration in the next cell cycle.Cell cycle (Georgetown, Tex.) · 2018Article
- Poly(adenosine diphosphate-ribose) polymerase as therapeutic target: lessons learned from its inhibitors.Oncotarget · 2017Review
- Marrow-derived cells regulate the development of early diabetic retinopathy and tactile allodynia in mice.Diabetes · 2012Article
- Signaling mechanism of poly(ADP-ribose) polymerase-1 (PARP-1) in inflammatory diseases.The American journal of pathology · 2011Review
- Stromal IFN-γR-signaling modulates goblet cell function during Salmonella Typhimurium infection.PloS one · 2011Article
- Article
- IL-17A/F-signaling does not contribute to the initial phase of mucosal inflammation triggered by S. Typhimurium.PloS one · 2010Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The immune system comprises an innate and an adaptive immune response to combat pathogenic agents. The human enteropathogen Salmonella enterica serovar Typhimurium invades the intestinal mucosa and triggers an early innate proinflammatory host gene response, which results in diarrheal disease. Several host factors, including transcription factors and transcription coregulators, are involved in the acute early response to Salmonella infection. We found in a mouse model of enterocolitis induced by S. Typhimurium that the absence of the nuclear protein poly(ADP-ribose) polymerase 1 (PARP1), a previously described cofactor for NF-kappaB-mediated proinflammatory gene expression, is associated with a delayed proinflammatory immune response after Salmonella infection. Our data reveal that PARP1 is expressed in the proliferative zone of cecum crypts, where it is required for the efficient expression of proinflammatory genes, many of which are related to interferon signaling. Consequently, animals lacking PARP1 show impaired infiltration of immune cells into the gut, with severely delayed inflammation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.