Evidence map›Paper›PMID 20515740›Full record

ReviewFrontiers in bioscience (Landmark edition)2010

TRPC channels in smooth muscle cells.

Jose C Gonzalez-Cobos, Mohamed Trebak

Open access · bronzeAbstract readReview
In one paragraph

Review in Frontiers in bioscience (Landmark edition), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
2.3field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 84 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Effects of aging on calcium channels in skeletal muscle.Frontiers in molecular biosciences · 2025
    Review
  6. Review
  7. The odyssey of the TR(i)P journey to the cellular membrane.Frontiers in cell and developmental biology · 2024
    Review
  8. Article
  9. A role for TRPC3 in mammalian testis development.Frontiers in cell and developmental biology · 2024
    Article
  10. Functional cooperation between IKCell proliferation · 2023
    Article
  11. Article
  12. Article
  13. Transient receptor potential cation channel 6 deficiency leads to increased body weight and metabolic dysfunction.American journal of physiology. Regulatory, integrative and comparative physiology · 2022
    Article
  14. Review
  15. Mechanotransduction in gastrointestinal smooth muscle cells: role of mechanosensitive ion channels.American journal of physiology. Gastrointestinal and liver physiology · 2021
    Review
  16. Review
  17. TRPC and TRPV Channels' Role in Vascular Remodeling and Disease.International journal of molecular sciences · 2020
    Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Jose C Gonzalez-CobosThe Center for Cardiovascular Sciences, Albany Medical College, Albany, NY, USA.
Mohamed Trebak
Albany Medical Center Hospital · US

Funding

Receptor-regulated Ca2+ Entry Pathways in Smooth MuscleR01HL097111 · NHLBI · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI TREBAK, MOHAMED · 2010 to 2019
$3.7M
Role of calcium and reactive oxygen species in toxicant-induced immune failureK22ES014729 · NIEHS · ALBANY MEDICAL COLLEGE · PI TREBAK, MOHAMED · 2007 to 2009
$448k
NHLBI NIH HHS R01 HL097111NIEHS NIH HHS K22 ES014729NIEHS NIH HHS K22ES014729
6 · The paper itself

Abstract

Transient receptor potential canonical (TRPC) proteins constitute a family of seven (TRPC1-7) nonselective cation channels within the wider TRP superfamily. TRPC1, TRPC3, TRPC4, TRPC5 and TRPC6 channels are expressed in vascular smooth muscle cells from human vessels of all calibers and in smooth muscle from organs such as the uterus and the gastrointestinal tract. TRPC channels have recently emerged as important players in the control of smooth muscle function. This review will focus on the retrospective analysis of studies proposing contributions of TRPC channels to native calcium entry pathways in smooth muscle and to physiological and pathophysiological responses with emphasis on the vascular system.

Indexed as

Signal TransductionCalciumFemaleGastrointestinal TractHumansMuscle, Smooth, VascularProtein IsoformsTRPC Cation ChannelsUterusVascular DiseasesCalciumProtein Isoformstransient receptor potential cation channel, subfamily C, member 1TRPC Cation Channels

Identifiers

PMID20515740
PMCPMC3164555
OpenAlexW1582323020

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.