ArticleGeneral and comparative endocrinology2010
Acquisition of spontaneous electrical activity during embryonic development of gonadotropin-releasing hormone-3 neurons located in the terminal nerve of transgenic zebrafish (Danio rerio).
Article in General and comparative endocrinology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 33 citations in OpenAlex.
- The Role and Mechanisms of the Hypocretin System in Zebrafish (International journal of molecular sciences · 2024Review
- The Olfactory Tract: Basis for Future Evolution in Response to Rapidly Changing Ecological Niches.Frontiers in neuroanatomy · 2022Review
- Cellular identity and CaScientific reports · 2020Article
- Sexual Dimorphic Distribution of Hypothalamic Tachykinin1 Cells and Their Innervations to GnRH Neurons in the Zebrafish.Frontiers in endocrinology · 2020Article
- Sensory Integration: Cross-Modal Communication Between the Olfactory and Visual Systems in Zebrafish.Chemical senses · 2019Review
- Neuroendocrinology of reproduction: Is gonadotropin-releasing hormone (GnRH) dispensable?Frontiers in neuroendocrinology · 2019Review
- Multiple functions of non-hypophysiotropic gonadotropin releasing hormone neurons in vertebrates.Zoological letters · 2019Review
- ZEBRAFISH AS AN IN VIVO MODEL FOR SUSTAINABLE CHEMICAL DESIGN.Green chemistry : an international journal and green chemistry resource : GC · 2016Article
- Morphological and Physiological Interactions Between GnRH3 and Hypocretin/Orexin Neuronal Systems in Zebrafish (Danio rerio).Endocrinology · 2016Article
- Zebrafish adult-derived hypothalamic neurospheres generate gonadotropin-releasing hormone (GnRH) neurons.Biology open · 2015Article
- Article
- Hedgehog-PKA signaling and gnrh3 regulate the development of zebrafish gnrh3 neurons.PloS one · 2014Article
- From seeing to believing: labelling strategies for in vivo cell-tracking experiments.Interface focus · 2013Article
- Recording electrical activity from identified neurons in the intact brain of transgenic fish.Journal of visualized experiments : JoVE · 2013Article
- Early development of the gonadotropin-releasing hormone neuronal network in transgenic zebrafish.Frontiers in endocrinology · 2013Article
- A conserved non-reproductive GnRH system in chordates.PloS one · 2012Article
- Characterization of voltage-activated ionic currents in the GnRH-containing terminalis nerve in transgenic zebrafish.Brain research · 2011Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
There are multiple populations of gonadotropin-releasing hormone (GnRH) neurons that have distinct physiological and behavioral functions. Teleost fish have a population of GnRH3 neurons located in the terminal nerve (TN) associated with the olfactory bulb that is thought to play a neuromodulatory role in multiple physiological systems, including olfactory, visual, and reproductive. We used transgenic zebrafish in which the GnRH3 promoter drives expression of a green fluorescent protein to identify GnRH3 neurons during development in live embryos. Unlike with hypophysiotropic GnRH neurons of zebrafish, TN-GnRH3 neurons are of neural crest origin and are one of the first populations of GnRH neurons to develop in the early embryo. Using a combination of optical imaging and electrophysiology, we showed that during the first 3 days post-fertilization, TN-GnRH3 neurons increase in number, extend neural projections, move in association with tissue expansion, and acquire an adult-pattern of spontaneous action potential firing. Early during development, about half of the neurons were quiescent/non-firing. Later, at 3 days post-fertilization, there was an increase in the proportion of neurons showing action potential firing and an increase in the number of neurons that showed an adult-like tonic or beating pattern of action potential firing with a firing frequency similar to that seen in adult TN-GnRH3 neurons. This study represents the first neurophysiological investigation of developing GnRH neurons in live embryos--an important advancement in understanding their potential non-reproductive roles during embryogenesis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.