Evidence map›Paper›PMID 20515283›Full record

ReviewScandinavian journal of clinical and laboratory investigation. Supplementum2010

Biomarkers for rheumatoid arthritis: making it personal.

Tamsin M Lindstrom, William H Robinson

Abstract readReview
In one paragraph

Review in Scandinavian journal of clinical and laboratory investigation. Supplementum, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Article
  4. Article
  5. Precision medicine in rheumatoid arthritis.Best practice & research. Clinical rheumatology · 2022
    Review
  6. Review
  7. Review
  8. The Progression of Hemophilic Arthropathy: The Role of Biomarkers.International journal of molecular sciences · 2020
    Review
  9. Article
  10. Article
  11. A Clinician's Perspective on Biomarkers.Focus (American Psychiatric Publishing) · 2018
    Review
  12. Synovial tissue research: a state-of-the-art review.Nature reviews. Rheumatology · 2017
    Review
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Tamsin M LindstromGeriatric Research Education and Clinical Center (GRECC), VA Palo Alto Health Care System, Palo Alto, CA, USA. tlind@stanford.edu
William H Robinson

Funding

The Role of Carboxypeptidase B and its Substrates in Rheumatoid ArthritisR01AI085268 · NIAID · STANFORD UNIVERSITY · PI ROBINSON, WILLIAM H · 2010 to 2013
$1.6M
Tyrosine Kinase Pathways in Rheumatoid ArthritisR01AR054822 · NIAMS · PALO ALTO VETERANS INSTIT FOR RESEARCH · PI ROBINSON, WILLIAM H · 2007 to 2011
$1.5M
Proteomic Identification of Actionable Biomarkers in Rheumatoid ArthritisRC1AR058713 · NIAMS · STANFORD UNIVERSITY · PI ROBINSON, WILLIAM H · 2009 to 2010
$1.0M
NIAID NIH HHS R01 AI085268NIAMS NIH HHS R01 AR-054822NIAMS NIH HHS R01 AR054822NIAMS NIH HHS RC1 AR058713
6 · The paper itself

Abstract

Effective treatment of rheumatoid arthritis (RA) has been hampered by the heterogeneity of the disease. Although early intervention can result in disease remission, it requires early diagnosis - and current diagnostic tests are not sufficiently accurate or sensitive in the early stages of RA. As a result, RA is typically diagnosed only once damage to the joints has already begun, a time at which the window for optimal treatment may have been missed. Furthermore, a significant proportion of RA patients do not respond to any given therapeutic. Research efforts are increasingly focused on discovery of biomarkers that enable early diagnosis and stratification of RA, and thus the implementation of timely, targeted therapy. Biomarkers have the potential to transform the management of RA by enabling not only early diagnosis, but also assessment and prediction of disease severity, selection of therapy, and monitoring of response to therapy. In this mini review, we discuss the development of molecular biomarkers for RA.

Indexed as

BiomarkersPrecision MedicineArthritis, RheumatoidAutoantibodiesGenomicsHumansProteomicsAutoantibodiesBiomarkers

Identifiers

PMID20515283
PMCPMC3417774

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.