ArticleTumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine2010
The role of NF-κB and PPARγ in experimentally induced colorectal cancer and chemoprevention by cyclooxygenase-2 inhibitors.
Article in Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 34 citations in OpenAlex.
- Synergistic antiproliferative effects of curcumin and celecoxib in hepatocellular carcinoma HepG2 cells.Naunyn-Schmiedeberg's archives of pharmacology · 2018Article
- TGF-β1 mediates the effects of aspirin on colonic tumor cell proliferation and apoptosis.Oncology letters · 2018Article
- NSAIDs: learning new tricks from old drugs.European journal of immunology · 2015Review
- Chemotherapy and chemoprevention by thiazolidinediones.BioMed research international · 2015Review
- Effect of a high-fat diet in development of colonic adenoma in an animal model.World journal of gastroenterology · 2014Article
- Chemopreventive drugs: mechanisms via inhibition of cancer stem cells in colorectal cancer.World journal of gastroenterology · 2014Review
- Article
- Induction but not inhibition of COX-2 confers human lung cancer cell apoptosis by celecoxib.Journal of lipid research · 2013Article
- NSAIDs may regulate EGR-1-mediated induction of reactive oxygen species and non-steroidal anti-inflammatory drug-induced gene (NAG)-1 to initiate intrinsic pathway of apoptosis for the chemoprevention of colorectal cancer.Molecular and cellular biochemistry · 2013Article
- A novel NSAID derivative, phospho-ibuprofen, prevents AOM-induced colon cancer in rats.International journal of oncology · 2013Article
- Simultaneous inhibition of COX-2 and activation of PPAR-γ resulted in the same level and pattern of neuroprotection as they were targeted separately.Journal of molecular neuroscience : MN · 2013Article
- Chemopreventive effects of non-steroidal anti-inflammatory drugs in early neoplasm of experimental colorectal cancer: an apoptosome study.Journal of gastrointestinal cancer · 2011Article
- Non steroidal anti-inflammatory drugs modulate the physicochemical properties of plasma membrane in experimental colorectal cancer: a fluorescence spectroscopic study.Molecular and cellular biochemistry · 2011Article
- NSAIDs and Cell Proliferation in Colorectal Cancer.Pharmaceuticals (Basel, Switzerland) · 2010Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Initiation of malignancy is dependent upon the basic ratio of cell proliferation and apoptosis. Many molecular proteins and pathways are responsible for the imbalance of proliferation and apoptosis ratio. For example, Akt is a key biomolecule which regulates the cell survival signals via various downstream pathways. One of those pathways is nuclear factor-κB activation which also regulates many downstream pathways that are essential for cell survival. Along with these anti-apoptotic pathways, cells do have a parallel mechanism to prevent malignancy with the help of the ligand-induced nuclear receptors, e.g., peroxisome proliferator-activated receptor gamma (PPARγ). PPARγ has been found to be expressed in many cancer cell types and reported to be a pro-apoptotic transcription factor. The study aimed to observe the ability of two cyclooxygenase-dependent non-steroidal anti-inflammatory drugs (NSAIDs) in the prevention of experimentally induced early neoplasm of colon via NF-κB and PPARγ pathways. Early stages of colorectal cancer were produced in rats with 1,2-dimethylhydrazine dihydrochloride. Western blotting and immunohistochemistry were performed along with morphological and histological analysis. According to the expression levels of NF-κB and PPARγ in the cell nuclei, it is observed that NSAIDs may prevent colorectal cancer in the early stages by a concomitant down-regulation of NF-κB and up-regulation of PPARγ. COX-independent mechanism of anti-carcinogenesis was observed by COX-dependent NSAIDs in colorectal cancer.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.