ArticleFrontiers in behavioral neuroscience2010
Pacemaker neuron and network oscillations depend on a neuromodulator-regulated linear current.
Article in Frontiers in behavioral neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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23 citing papers in PubMed, 68 citations in OpenAlex.
- Oscillatory network spontaneously recovers both activity and robustness after prolonged removal of neuromodulators.Frontiers in cellular neuroscience · 2023Article
- Neuromodulation Enables Temperature Robustness and Coupling Between Fast and Slow Oscillator Circuits.Frontiers in cellular neuroscience · 2022Article
- Neuropeptide Modulation Increases Dendritic Electrical Spread to Restore Neuronal Activity Disrupted by Temperature.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Mutual Suppression of Proximal and Distal Axonal Spike Initiation Determines the Output Patterns of a Motor Neuron.Frontiers in cellular neuroscience · 2019Article
- Control of transitions between locomotor-like and paw shake-like rhythms in a model of a multistable central pattern generator.Journal of neurophysiology · 2018Article
- Cellular Effects of Repetition Priming in theThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- A balance of outward and linear inward ionic currents is required for generation of slow-wave oscillations.Journal of neurophysiology · 2017Article
- Activation mechanism of a neuromodulator-gated pacemaker ionic current.Journal of neurophysiology · 2017Article
- The complexity of small circuits: the stomatogastric nervous system.Current opinion in neurobiology · 2016Review
- Network feedback regulates motor output across a range of modulatory neuron activity.Journal of neurophysiology · 2016Article
- Differential effects of conductances on the phase resetting curve of a bursting neuronal oscillator.Journal of computational neuroscience · 2015Article
- Neuromodulation to the Rescue: Compensation of Temperature-Induced Breakdown of Rhythmic Motor Patterns via Extrinsic Neuromodulatory Input.PLoS biology · 2015Article
- The role of linear and voltage-dependent ionic currents in the generation of slow wave oscillations.Journal of computational neuroscience · 2014Article
- Article
- Cycle-by-cycle assembly of respiratory network activity is dynamic and stochastic.Journal of neurophysiology · 2013Article
- NALCN: a regulator of pacemaker activity.Molecular neurobiology · 2012Review
- Neuromodulation independently determines correlated channel expression and conductance levels in motor neurons of the stomatogastric ganglion.Journal of neurophysiology · 2012Article
- Tonic dopamine induces persistent changes in the transient potassium current through translational regulation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- The membrane potential waveform of bursting pacemaker neurons is a predictor of their preferred frequency and the network cycle frequency.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Cell specific dopamine modulation of the transient potassium current in the pyloric network by the canonical D1 receptor signal transduction cascade.Journal of neurophysiology · 2010Article
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3 authors at 1 institution in 1 country.
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Abstract
Linear leak currents have been implicated in the regulation of neuronal excitability, generation of neuronal and network oscillations, and network state transitions. Yet, few studies have directly tested the dependence of network oscillations on leak currents or explored the role of leak currents on network activity. In the oscillatory pyloric network of decapod crustaceans neuromodulatory inputs are necessary for pacemaker activity. A large subset of neuromodulators is known to activate a single voltage-gated inward current I(MI), which has been shown to regulate the rhythmic activity of the network and its pacemaker neurons. Using the dynamic clamp technique, we show that the crucial component of I(MI) for the generation of oscillatory activity is only a close-to-linear portion of the current-voltage relationship. The nature of this conductance is such that the presence or the absence of neuromodulators effectively regulates the amount of leak current and the input resistance in the pacemaker neurons. When deprived of neuromodulatory inputs, pyloric oscillations are disrupted; yet, a linear reduction of the total conductance in a single neuron within the pacemaker group recovers not only the pacemaker activity in that neuron, but also leads to a recovery of oscillations in the entire pyloric network. The recovered activity produces proper frequency and phasing that is similar to that induced by neuromodulators. These results show that the passive properties of pacemaker neurons can significantly affect their capacity to generate and regulate the oscillatory activity of an entire network, and that this feature is exploited by neuromodulatory inputs.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.