ArticleJournal of Korean medical science2010
Enhancement of gastric ulcer healing and angiogenesis by cochinchina Momordica seed extract in rats.
Article in Journal of Korean medical science, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 48 citations in OpenAlex.
- Prevention of NSAID-associated gastroduodenal injury in healthy volunteers-a randomized, double-blind, multicenter study comparing DA-9601 with misoprostol.Journal of Korean medical science · 2011Trial
- Dietary supplementation with gac (<em>Momordica cochinchinensis</em>) aril powder and oil enhances coloration, hemato-biochemical parameters, and immunity-related gene expression in ornamental goldfish.Veterinary world · 2026Article
- Momordicae Semen: A Review of Phytochemistry, Pharmacology, Toxicology, Herbal Processing, Clinical Applications, and Q-Markers Prediction.Drug design, development and therapy · 2025Review
- Hepatoprotective Effects of Gac (Journal of experimental pharmacology · 2025Article
- Background factors of idiopathic peptic ulcers and optimal treatment methods: a multicenter retrospective Japanese study.Journal of clinical biochemistry and nutrition · 2024Article
- Glucagon-like peptide-2 protects the gastric mucosaFrontiers in endocrinology · 2022Article
- Therapeutic approach of adipose-derived mesenchymal stem cells in refractory peptic ulcer.Stem cell research & therapy · 2021Review
- Hydromethanolic Crude Extract of the Leaf ofEvidence-based complementary and alternative medicine : eCAM · 2021Article
- A Potential Anti-Tumor Herb Bred in a Tropical Fruit: Insight into the Chemical Components and Pharmacological Effects of Momordicae Semen.Molecules (Basel, Switzerland) · 2019Review
- Bioactive Composition, Antioxidant Activity, and Anticancer Potential of Freeze-Dried Extracts from Defatted Gac (Medicines (Basel, Switzerland) · 2018Article
- Optimisation of the Microwave-Assisted Ethanol Extraction of Saponins from Gac (Medicines (Basel, Switzerland) · 2018Article
- Enhancement of Gastric Ulcer Healing and Angiogenesis by Hepatocyte Growth Factor Gene Mediated by Attenuated Salmonella in Rats.Journal of Korean medical science · 2017Article
- Manuka Honey Exerts Antioxidant and Anti-Inflammatory Activities That Promote Healing of Acetic Acid-Induced Gastric Ulcer in Rats.Evidence-based complementary and alternative medicine : eCAM · 2017Article
- Neurotrophic Effects of Mu Bie Zi (Momordica cochinchinensis) Seed Elucidated by High-Throughput Screening of Natural Products for NGF Mimetic Effects in PC-12 Cells.Neurochemical research · 2015Article
- Efficacy and safety of herbal medicines in treating gastric ulcer: a review.World journal of gastroenterology · 2014Review
- The Effect of Cochinchina momordica Seed Extract on Gastric Acid Secretion and Morphologic Change in Aged Rat Stomach.Gut and liver · 2013Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cochinchina momordica seed is the dried ripe seed of Momordica cochinchinensis, a perennial vine. The antiulcer effect of an extract from cochinchina momordica seeds (SK-MS10) was evaluated in a rat model of acetic acid-induced gastric ulcers. Gastric ulcers were produced by subserosal injection of acetic acid. SK-MS10 (200 mg/kg) or vehicle was administered orally once per day for 14 days after the acetic acid injection. The stomach was removed and the ulcer size measured at day 7 and 14 of the treatment. Expression of vascular endothelial growth factor (VEGF) was assessed by real-time RT-PCR and Western blot analysis. In addition, the microvasculature density (MVD) adjacent to the ulcer margin was examined by immunohistochemistry. The treatment with SK-MS10 for 7 and 14 days significantly accelerated ulcer healing and increased the expression of mRNA (at day 7) as well as VEGF protein (at day 14) compared to the vehicle-treated rats. The MVD for factor VIII was also higher in the SK-MS10 treatment group compared to the vehicle-treated rats; however, these differences were not statistically significant. These results suggest that SK-MS10 treatment accelerates the healing of gastric ulcers via upregulation of VEGF and angiogenesis in an acetic acid rat model.
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