ArticleActa histochemica et cytochemica2010
Immunohistochemical examination on the distribution of cells expressed lymphatic endothelial marker podoplanin and LYVE-1 in the mouse tongue tissue.
Article in Acta histochemica et cytochemica, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 37 citations in OpenAlex.
- The role of the lymphatic system in musculoskeletal system health and disease: research progress and future directions.Bone research · 2026Review
- Meningeal lymphatic architecture and drainage dynamics surrounding the human middle meningeal artery.iScience · 2025Article
- Lymphatic dysfunction correlates with inflammation in a mouse model of amyotrophic lateral sclerosis.Disease models & mechanisms · 2025Article
- Podoplanin is dispensable for mineralized tissue formation and maintenance in the Swiss outbred mouse background.Genesis (New York, N.Y. : 2000) · 2021Article
- Expression of Lymphatic Markers in the Berger's Space and Bursa Premacularis.International journal of molecular sciences · 2021Article
- Effect of VEGFC on lymph flow and inflammation-induced alveolar bone loss.The Journal of pathology · 2020Article
- Attenuated Joint Tissue Damage Associated With Improved Synovial Lymphatic Function Following Treatment With Bortezomib in a Mouse Model of Experimental Posttraumatic Osteoarthritis.Arthritis & rheumatology (Hoboken, N.J.) · 2019Article
- Lymphatic Vessel Network Structure and Physiology.Comprehensive Physiology · 2018Review
- Regression of Lingual Lymphatic Vessels in Sodium-restricted Mice.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2018Article
- Article
- Differentiation of Apical Bud Cells in a Newly Developed Apical Bud Transplantation Model Using GFP Transgenic Mice as Donor.PloS one · 2016Article
- Distribution and alteration of lymphatic vessels in knee joints of normal and osteoarthritic mice.Arthritis & rheumatology (Hoboken, N.J.) · 2014Article
- Distribution of podoplanin-expressing cells in the mouse nervous systems.Acta histochemica et cytochemica · 2013Article
- Use of a whole-slide imaging system to assess the presence and alteration of lymphatic vessels in joint sections of arthritic mice.Biotechnic & histochemistry : official publication of the Biological Stain Commission · 2013Article
- Altered dynamics in the renal lymphatic circulation of type 1 and type 2 diabetic mice.Acta histochemica et cytochemica · 2013Article
- Characterization of cells expressing lymphatic marker LYVE-1 in macaque large intestine during simian immunodeficiency virus infection identifies a large population of nonvascular LYVE-1(+)/DC-SIGN(+) cells.Lymphatic research and biology · 2013Article
- Expression of Toll-Like Receptor 4 in Glomerular Endothelial Cells under Diabetic Conditions.Acta histochemica et cytochemica · 2013Article
- Immunohistochemical Examination of Novel Rat Monoclonal Antibodies against Mouse and Human Podoplanin.Acta histochemica et cytochemica · 2012Article
- The expression of podoplanin and classic cadherins in the mouse brain.Journal of anatomy · 2012Article
- Interaction of protein phosphatase 1δ with nucleophosmin in human osteoblastic cells.Acta histochemica et cytochemica · 2012Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The clinical study for lingual disease requires the detailed investigation of the lingual lymphatic network and lymphatic marker-positive cells. Recently, it has been reported that several tissue cells and leukocytes express lymphatic markers, LYVE-1 and podoplanin. This study was aimed to clarify the lingual distribution of cells expressing LYVE-1 and podoplanin. In the mouse tongue, podoplanin is expressed in nerve sheaths, lingual gland myoepithelial cells, and lymphatic vessels. LYVE-1 is expressed in the macrophage marker Mac-1-positive cells as well as lymphatic vessels, while factor-VIII was detected in only blood endothelial cells. α-SMA was detected in vascular smooth muscle and myoepithelial cells. Therefore, identification of lymphatic vessels in lingual glands, the combination of LYVE-1 and factor-VIII, or LYVE-1 and Mac-1 is useful because myoepithelial cells express podoplanin and α-SMA. The immunostaining of factor-VIII on lymphatic vessels was masked by the immunostaining to LYVE-1 or podoplanin because lymphatic vessels express factor-VIII to a far lesser extent than blood vessels. Therefore, except for the salivary glands, the combination of podoplanin and α-SMA, or factor-VIII is useful to identify lymphatic vessels and blood vessels with smooth muscle, or blood capillaries.
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