ArticleCurrent genomics2009
Getting a grip on complexes.
Article in Current genomics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 25 citations in OpenAlex.
- Application and research progress of MultiBac: A review.Medicine · 2024Review
- VLP-factory™ and ADDomerCurrent protocols · 2021Article
- MultiBac: Baculovirus-Mediated Multigene DNA Cargo Delivery in Insect and Mammalian Cells.Viruses · 2019Review
- Efficient production of a mature and functional gamma secretase protease.Scientific reports · 2018Article
- Review
- Protein Complex Affinity Capture from Cryomilled Mammalian Cells.Journal of visualized experiments : JoVE · 2016Article
- The MultiBac Baculovirus/Insect Cell Expression Vector System for Producing Complex Protein Biologics.Advances in experimental medicine and biology · 2016Review
- Affinity proteomics to study endogenous protein complexes: pointers, pitfalls, preferences and perspectives.BioTechniques · 2015Article
- Multiprotein complex production in insect cells by using polyproteins.Methods in molecular biology (Clifton, N.J.) · 2014Article
- The multiBac protein complex production platform at the EMBL.Journal of visualized experiments : JoVE · 2013Article
- MultiBac: expanding the research toolbox for multiprotein complexes.Trends in biochemical sciences · 2012Review
- Article
- Robots, pipelines, polyproteins: enabling multiprotein expression in prokaryotic and eukaryotic cells.Journal of structural biology · 2011Review
- Gene gymnastics: Synthetic biology for baculovirus expression vector system engineering.BioengineeredArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We are witnessing tremendous advances in our understanding of the organization of life. Complete genomes are being deciphered with ever increasing speed and accuracy, thereby setting the stage for addressing the entire gene product repertoire of cells, towards understanding whole biological systems. Advances in bioinformatics and mass spectrometric techniques have revealed the multitude of interactions present in the proteome. Multiprotein complexes are emerging as a paramount cornerstone of biological activity, as many proteins appear to participate, stably or transiently, in large multisubunit assemblies. Analysis of the architecture of these assemblies and their manifold interactions is imperative for understanding their function at the molecular level. Structural genomics efforts have fostered the development of many technologies towards achieving the throughput required for studying system-wide single proteins and small interaction motifs at high resolution. The present shift in focus towards large multiprotein complexes, in particular in eukaryotes, now calls for a likewise concerted effort to develop and provide new technologies that are urgently required to produce in quality and quantity the plethora of multiprotein assemblies that form the complexome, and to routinely study their structure and function at the molecular level. Current efforts towards this objective are summarized and reviewed in this contribution.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.