Evidence map›Paper›PMID 20514045›Full record

ReviewNature reviews. Microbiology2010

Periodontitis: a polymicrobial disruption of host homeostasis.

Richard P Darveau

Registry-linked trialAbstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Microbiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07397026 (Clinical and Laboratory Evaluation of Resveratrol Loaded Nanoparticles in the Treatment of Periodontitis), which is not on this map. Cited by 877 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
877citing papers in PubMed, 9 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07397026 phase1active not recruitingnot on this mapstarted 2025, after this paper: background citation

Clinical and Laboratory Evaluation of Resveratrol Loaded Nanoparticles in the Treatment of Periodontitis: A Randomized Controlled Clinical Trial

TypeinterventionalSponsorHagar Ahmed Ali Mohammed ElzainRan2025 to 2026Enrolled48ConditionsPeriodontitis Stage IIIArmsResveratrol loaded gel
3 · Its place in the literature

Who cites it

877 citing papers in PubMed, 9 syntheses or guidelines pooled it.

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  19. Markerless gene deletion inMicrobiology spectrum · 2026
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817 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Richard P DarveauUniversity of Washington, Seattle, Washington 98195, USA. rdarveau@u.washington.edu

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Periodontitis, or gum disease, affects millions of people each year. Although it is associated with a defined microbial composition found on the surface of the tooth and tooth root, the contribution of bacteria to disease progression is poorly understood. Commensal bacteria probably induce a protective response that prevents the host from developing disease. However, several bacterial species found in plaque (the 'red-complex' bacteria: Porphyromonas gingivalis, Tannerella forsythia and Treponema denticola) use various mechanisms to interfere with host defence mechanisms. Furthermore, disease may result from 'community-based' attack on the host. Here, I describe the interaction of the host immune system with the oral bacteria in healthy states and in diseased states.

Indexed as

AnimalsBacterial Physiological PhenomenaBiofilmsHumansPeriodontitisPeriodontiumPorphyromonas gingivalisTreponema denticola

Identifiers

PMID20514045

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.