ArticleJournal of the Royal Society of Medicine2010
Ten-year trends in hospital admissions for adverse drug reactions in England 1999-2009.
Article in Journal of the Royal Society of Medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 3 of them syntheses that pooled it.
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Who cites it
56 citing papers in PubMed, 3 syntheses or guidelines pooled it, 169 citations in OpenAlex.
- Hospitalizations and deaths related to adverse drug events worldwide: Systematic review of studies with national coverage.European journal of clinical pharmacology · 2022Pooled it
- A systematic review of hospitalization resulting from medicine-related problems in adult patients.British journal of clinical pharmacology · 2014Pooled it
- ICD-10 codes used to identify adverse drug events in administrative data: a systematic review.Journal of the American Medical Informatics Association : JAMIAPooled it
- Nurse-Led Medicines' Monitoring for Patients with Dementia in Care Homes: A Pragmatic Cohort Stepped Wedge Cluster Randomised Trial.PloS one · 2015Trial
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- Predictors of Adverse Drug Reaction-Related Hospitalisations Among People with Dementia: A Retrospective Case-Control Study.Drug safety · 2024Article
- Current Practices of Medication Plans in Austrian Patients Undergoing Coronary Angiography: An In-Depth Analysis.Journal of clinical medicine · 2024Article
- Risk factors for medication-related short-term readmissions in adults - a scoping review.BMC health services research · 2023Article
- Incidence and preventability of hospital admissions for adverse drug reactions in France: A prospective observational study (IATROSTAT).British journal of clinical pharmacology · 2023Observational
- Trends and characteristics of hospitalisations from the harmful use of opioids in England between 2008 and 2018: Population-based retrospective cohort study.Journal of the Royal Society of Medicine · 2022Article
- Hospitalizations and adverse drug events in the Brazilian unified health system: a ten-year retrospective analysis of routine data.Revista de saude publica · 2022Article
- A National Survey of Community Pharmacists' Viewpoints About Pharmacovigilance and Adverse Drug Reaction Reporting in Saudi Arabia.Frontiers in pharmacology · 2022Article
- Analysis of fatal adverse drug events recorded in several Italian emergency departments (the MEREAFaPS study).Internal and emergency medicine · 2021Article
- Rapid review of suspected adverse drug events due to remdesivir in the WHO database; findings and implications.Expert review of clinical pharmacology · 2021Article
- Skills and practices of pharmacy staff for dispensing of drugs with fiscalized substances in drugstores and pharmacies.Revista de saude publica · 2021Article
- Nobody ever questions-Polypharmacy in care homes: A mixed methods evaluation of a multidisciplinary medicines optimisation initiative.PloS one · 2021Article
- Hematologic adverse drug reactions leading to hospitalization among cancer patients: A retrospective case-control study.Journal of the Chinese Medical Association : JCMA · 2020Article
- Broad-Spectrum Profiling of Drug Safety via Learning Complex Network.Clinical pharmacology and therapeutics · 2020Article
- Medicines reconciliation at the community mental health team-general practice interface: quality improvement study.BJPsych bulletin · 2020Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesAdverse drug reactions (ADR) are an important cause of morbidity and mortality. We analysed trends in hospital admissions associated with ADRs in English hospitals between 1999 and 2008.
designData from the Hospital Episode Statistics database were examined for all English hospital admissions (1999-2008) with a primary or secondary diagnosis of an ADR recorded.
settingAll NHS (public) hospitals in England.
main outcome measuresThe number of admissions and in-hospital mortality rate with a primary (codes including 'adverse drug reaction', 'drug-induced', 'due to drug', 'due to medicament' or 'drug allergy') or secondary diagnosis of ADR (ICD-10 Y40-59) were obtained and analysed. Further analysis for the year 2008-2009 was performed with regard to age, gender, proportion aged >65 yrs and total bed-days.
resultsBetween 1999 and 2008, there were 557,978 ADR-associated admissions, representing 0.9% of total hospital admissions. Over this period the annual number of ADRs increased by 76.8% (from 42,453 to 75,076), and in-hospital mortality rate increased by 10% (from 4.3% to 4.7%). In 2008, there were 6,830,067 emergency admissions of which 75,076 (1.1%) were drug-related. Systemic agents were most commonly implicated (19.2%), followed by analgesics (13.3%) and cardiovascular drugs (12.9%).There has been a near two-fold increase in nephropathy and cardiovascular consequences secondary to drugs and a 6.8% fall in mental and behavioural disorders due to drugs. Conclusions ADRs have a major impact on public health. Our data suggest the number of ADR admissions has increased at a greater rate than the increase in total hospital admissions; some of this may be due to improved diagnostic coding. However, in-hospital mortality due to ADR admissions also increased during the period. Our findings should prompt policymakers to implement further measures to reduce ADR incidence and their associated in-hospital mortality, and methods to improve the recording of ADRs.
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