SynthesisThe British journal of psychiatry : the journal of mental science2010
Efficacy of atypical v. typical antipsychotics in the treatment of early psychosis: meta-analysis.
Synthesis in The British journal of psychiatry : the journal of mental science, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
57 citing papers in PubMed, 6 syntheses or guidelines pooled it, 151 citations in OpenAlex.
- Systematic Review and Meta-analysis of Exercise Interventions for Psychotic Disorders: The Impact of Exercise Intensity, Mindfulness Components, and Other Moderators on Symptoms, Functioning, and Cardiometabolic Health.Schizophrenia bulletin · 2024Pooled it
- New-onset psychosis following COVID-19 vaccination: a systematic review.Frontiers in psychiatry · 2024Pooled it
- Are Patients WithFrontiers in pharmacology · 2019Pooled it
- Guidelines for the Pharmacotherapy of Schizophrenia in Adults.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2017Pooled it
- Atypical antipsychotics for psychosis in adolescents.The Cochrane database of systematic reviews · 2013Pooled it
- Efficacy and safety of individual second-generation vs. first-generation antipsychotics in first-episode psychosis: a systematic review and meta-analysis.The international journal of neuropsychopharmacology · 2013Pooled it
- Potential diagnostic markers of olanzapine efficiency for acute psychosis: a focus on peripheral biogenic amines.BMC psychiatry · 2017Trial
- Cariprazine in the treatment of schizophrenia: a proof-of-concept trial.International clinical psychopharmacology · 2016Trial
- Treatment of methamphetamine-induced psychosis: a double-blind randomized controlled trial comparing haloperidol and quetiapine.Psychopharmacology · 2014Trial
- The prevalence of antipsychotic polypharmacy and its associations with violent behaviors among forensic psychiatry patients.BMC psychiatry · 2026Article
- Polyunsaturated fatty acids and psychotic disorders: integrating mechanistic, genetic, and clinical evidence.Frontiers in nutrition · 2026Review
- Prescribing Patterns and Adverse Reactions of Antipsychotics in a North Indian Psychiatry Outpatient Department.Cureus · 2025Article
- Metabolic syndrome and its components are associated with lengths of stay in a psychiatric hospital: Results from a Swiss psychiatric cohort and first-episode psychosis patients.European psychiatry : the journal of the Association of European Psychiatrists · 2025Article
- Evaluation of Prescription Patterns of Antipsychotics in Schizophrenia Patients-A Single-Center Prospective Study.Journal of clinical medicine · 2025Article
- Gait Disturbance in Patients with Schizophrenia in Relation to Walking Speed, Ankle Joint Range of Motion, Body Composition, and Extrapyramidal Symptoms.Healthcare (Basel, Switzerland) · 2025Article
- Trajectories of daily antipsychotic use and weight gain in people hospitalized for the first episode of psychosis.European psychiatry : the journal of the Association of European Psychiatrists · 2024Article
- Comparing interventions for early psychosis: a systematic review and component network meta-analysis.EClinicalMedicine · 2024Article
- Perphenazine in Treatment-Resistant Schizophrenia.Cureus · 2024Article
- Knowledge and dispensing practice of community pharmacists towards antipsychotic medicines in a Nigerian metropolitan city - a cross-sectional study.BMC health services research · 2023Article
- Momentary Self-esteem as a Process Underlying the Association Between Childhood Trauma and Psychosis: Experience Sampling Study.JMIR mental health · 2023Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere is an ongoing debate about the use of atypical antipsychotics as a first-line treatment for first-episode psychosis.
aimsTo examine the evidence base for this recommendation.
methodMeta-analyses of randomised controlled trials in the early phase of psychosis, looking at long-term discontinuation rates, short-term symptom changes, weight gain and extrapyramidal side-effects. Trials were identified using a combination of electronic (Cochrane Central, EMBASE, MEDLINE and PsycINFO) and manual searches.
resultsFifteen randomised controlled trials with a total of 2522 participants were included. No significant differences between atypical and typical drugs were found for discontinuation rates (odds ratio (OR) = 0.7, 95% CI 0.4 to 1.2) or effect on symptoms (standardised mean difference (SMD) = -0.1, 95% CI -0.2 to 0.02). Participants on atypical antipsychotics gained 2.1 kg (95% CI 0.1 to 4.1) more weight than those on typicals, whereas those on typicals experienced more extrapyramidal side-effects (SMD = -0.4, 95% CI -0.5 to -0.2).
conclusionsThere was no evidence for differences in efficacy between atypical and typical antipsychotics, but there was a clear difference in the side-effect profile.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.