Evidence map›Paper›PMID 20513828›Full record

Trial reportAnnals of internal medicine2010

Clinic-based treatment of opioid-dependent HIV-infected patients versus referral to an opioid treatment program: A randomized trial.

Gregory M Lucas, Amina Chaudhry, Jeffrey Hsu, Tanita Woodson, Bryan Lau, Yngvild Olsen, Jeanne C Keruly, David A Fiellin, Ruth Finkelstein, Patricia Barditch-Crovo and 2 more

2 registry-linked trialsOpen access · greenAbstract readComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Annals of internal medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 80 papers, 15 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
80citing papers in PubMed, 15 pooled it
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00130819 phase2completednot on this map

Buprenorphine Effectiveness Evaluation in HIV Enhancement (BEEHIVE): A Randomized Trial of HIV Clinic-based Buprenorphine/Naloxone vs. Case Management and Referral in Opioid-dependent Individuals

TypeinterventionalSponsorJohns Hopkins UniversityRan2005 to 2009Enrolled120ConditionsOpiate Dependence, HIV Seropositivity, HIV InfectionsArmsClinic-based substance abuse treatment with buprenorphine, Case management and referred substance abuse treatment
NCT04601064 naactive not recruitingnot on this mapstarted 2022, after this paper: background citation

Peer Supported Collaborative Care to Increase Engagement in Mental Health and Substance Use Disorder Care in HIV Care Settings

TypeinterventionalSponsorJohns Hopkins UniversityRan2022 to 2026Enrolled405ConditionsHIV Infections, Substance Use Disorders, Mental Health Disorder, AddictionArmsCollaborative Care Model
3 · Its place in the literature

Who cites it

80 citing papers in PubMed, 15 syntheses or guidelines pooled it, 115 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Mental health and retention in HIV care: A systematic review and meta-analysis.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2018
    Pooled it
  7. Pooled it
  8. Pooled it
  9. Pooled it
  10. Pooled it
  11. Pooled it
  12. Pooled it
  13. Guideline
  14. Pooled it
  15. Guideline
  16. Trial
  17. Trial
  18. Trial
  19. Trial
  20. Trial

20 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Gregory M LucasJohns Hopkins University School of Medicine, Baltimore, Maryland, USA. glucas@jhmi.edu
Amina Chaudhry
Jeffrey Hsu
Tanita Woodson
Bryan Lau
Yngvild Olsen
Jeanne C Keruly
David A Fiellin
Ruth Finkelstein
Patricia Barditch-Crovo
Katie Cook
Richard D Moore
New York Academy of Medicine · USUnited States Department of Health and Human Services · US

Funding

Institute for Clinical and Translational Research (UL1)UL1RR025005 · NCRR · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2007 to 2011
$75.8M
ZINC AND CA EDTA THERAPY OF PLUMBISMM01RR000052 · NCRR · JOHNS HOPKINS UNIVERSITY · PI BELCHER, HAROLYN MILLICENT EDITH · 1985 to 2007
$37.3M
Johns Hopkins HIV Clinical CohortU01DA036935 · NIDA · JOHNS HOPKINS UNIVERSITY · PI MOORE, RICHARD DOUGLAS · 2014 to 2024
$14.9M
HIV DISEASE OUTCOMES IN DRUG USERS IN CLINICAL PRACTICER01DA011602 · NIDA · JOHNS HOPKINS UNIVERSITY · PI MOORE, RICHARD DOUGLAS · 1998 to 2013
$10.8M
Models of SBIRT for Opioid Dependent Patients in the Emergency DepartmentR01DA025991 · NIDA · YALE UNIVERSITY · PI D'ONOFRIO, GAIL, FIELLIN, DAVID · 2008 to 2012
$4.8M
DIRECTLY ADMINISTERERD HIV THERAPY IN METHADONE CLINICSR01DA018577 · NIDA · JOHNS HOPKINS UNIVERSITY · PI LUCAS, GREGORY M · 2005 to 2009
$2.9M
Buprenorphine Maintenance vs. Detoxification in Prescription Opioid DependenceR01DA020576 · NIDA · YALE UNIVERSITY · PI FIELLIN, DAVID · 2007 to 2011
$2.9M
Counseling for Primary Care Office-Based BuprenorphineR01DA019511 · NIDA · YALE UNIVERSITY · PI FIELLIN, DAVID · 2005 to 2009
$2.8M
MID CAREER INVESTIGATOR AWARDK24DA000432 · NIDA · JOHNS HOPKINS UNIVERSITY · PI MOORE, RICHARD DOUGLAS · 2000 to 2009
$1.5M
Alcohol and HIV Treatment and Clinical ProgressionR01AA016893 · NIAAA · JOHNS HOPKINS UNIVERSITY · PI MOORE, RICHARD DOUGLAS · 2008 to 2011
$1.3M
Directly observed antiretroviral therapy in drug abusersK23DA015616 · NIDA · JOHNS HOPKINS UNIVERSITY · PI LUCAS, GREGORY M · 2002 to 2006
$784k
Biomarkers, Therapy, and Mortality in the Evolving HIV EpidemicK01AI071754 · NIAID · JOHNS HOPKINS UNIVERSITY · PI LAU, BRYAN · 2007 to 2011
$662k
NCRR NIH HHS M01 RR000052NCRR NIH HHS UL1 RR 025005NCRR NIH HHS UL1 RR025005NIAAA NIH HHS R01 AA016893NIAAA NIH HHS R01AA016893NIAID NIH HHS K01 AI071754NIAID NIH HHS K01AI071754NIDA NIH HHS K23 DA015616NIDA NIH HHS K23DA015616NIDA NIH HHS K24 DA000432NIDA NIH HHS K24DA000432NIDA NIH HHS R01 DA011602NIDA NIH HHS R01DA011602NIDA NIH HHS R01 DA018577NIDA NIH HHS R01DA018577NIDA NIH HHS R01 DA019511NIDA NIH HHS R01DA019511NIDA NIH HHS R01 DA020576NIDA NIH HHS R01DA020576NIDA NIH HHS R01 DA025991NIDA NIH HHS R01DA025991NIDA NIH HHS U01 DA036935
6 · The paper itself

Abstract

backgroundOpioid dependence is common in HIV clinics. Buprenorphine-naloxone (BUP) is an effective treatment of opioid dependence that may be used in routine medical settings.

objectiveTo compare clinic-based treatment with BUP (clinic-based BUP) with case management and referral to an opioid treatment program (referred treatment).

designSingle-center, 12-month randomized trial. Participants and investigators were aware of treatment assignments. (ClinicalTrials.gov registration number: NCT00130819)

settingHIV clinic in Baltimore, Maryland. PATIENTS: 93 HIV-infected, opioid-dependent participants who were not receiving opioid agonist therapy and were not dependent on alcohol or benzodiazepines.

interventionClinic-based BUP included BUP induction and dose titration, urine drug testing, and individual counseling. Referred treatment included case management and referral to an opioid-treatment program. MEASUREMENTS: Initiation and long-term receipt of opioid agonist therapy, urine drug test results, visit attendance with primary HIV care providers, use of antiretroviral therapy, and changes in HIV RNA levels and CD4 cell counts.

resultsThe average estimated participation in opioid agonist therapy was 74% (95% CI, 61% to 84%) for clinic-based BUP and 41% (CI, 29% to 53%) for referred treatment (P < 0.001). Positive test results for opioids and cocaine were significantly less frequent in clinic-based BUP than in referred treatment, and study participants receiving clinic-based BUP attended significantly more HIV primary care visits than those receiving referred treatment. Use of antiretroviral therapy and changes in HIV RNA levels and CD4 cell counts did not differ between the 2 groups. LIMITATION: This was a small single-center study, follow-up was only moderate, and the study groups were unbalanced in terms of recent drug injections at baseline.

conclusionManagement of HIV-infected, opioid-dependent patients with a clinic-based BUP strategy facilitates access to opioid agonist therapy and improves outcomes of substance abuse treatment. PRIMARY FUNDING SOURCE: Health Resources and Services Administration Special Projects of National Significance program.

Indexed as

Anti-HIV AgentsBaltimoreBuprenorphineCommunity Health ServicesDrug Therapy, CombinationHIV InfectionsHumansNaloxoneNarcotic AntagonistsOpioid-Related DisordersOutcome Assessment, Health CareReferral and ConsultationSubstance Abuse Treatment CentersTreatment OutcomeAnti-HIV AgentsBuprenorphineNaloxoneNarcotic Antagonists

Identifiers

PMID20513828
PMCPMC2886293
OpenAlexW2113539869

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.