ArticleThe Journal of experimental medicine2010
Innate immunity defines the capacity of antiviral T cells to limit persistent infection.
Article in The Journal of experimental medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 132 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
132 citing papers in PubMed, 203 citations in OpenAlex.
- Unconventional functions of natural killer cells in homeostasis and disease.Journal of immunology (Baltimore, Md. : 1950) · 2026Review
- Phenotypically similar but functionally distinct NK cell populations within the human maternal-fetal interface.ImmunoHorizons · 2026Article
- Dendritic Cell Organization and Function in Innate and Adaptive Immune Defense Within Lymph Nodes.Immunological reviews · 2026Review
- Natural killer cells and IFN-γ protect against liver injury during HAV infection in mice.Journal of virology · 2025Article
- AWT020: a novel fusion protein harnessing PD-1 blockade and selective IL-2 Cis-activation for enhanced anti-tumor immunity and diminished toxicity.Frontiers in immunology · 2025Article
- Heightened innate immune state induced by viral vector leads to enhanced response to challenge and prolongs malaria vaccine protection.iScience · 2024Article
- The Multifaceted Roles of NK Cells in the Context of Murine Cytomegalovirus and Lymphocytic Choriomeningitis Virus Infections.Immune network · 2024Review
- Tissue-resident memory NK cells: Homing in on local effectors and regulators.Immunological reviews · 2024Review
- Germline natural killer cell receptors modulating the T cell response.Frontiers in immunology · 2024Review
- Innate receptors modulating adaptive T cell responses: KIR-HLA interactions and T cell-mediated control of chronic viral infections.Immunogenetics · 2023Review
- Article
- Balancing act: the complex role of NK cells in immune regulation.Frontiers in immunology · 2023Review
- Review
- Efficacy and Safety of Lithium Treatment in SARS-CoV-2 Infected Patients.Frontiers in pharmacology · 2022Article
- Disturbed natural killer cell homeostasis in the salivary gland enhances autoimmune pathologyFrontiers in medicine · 2022Article
- Hemagglutinin protein of Peste des Petits Ruminants virus (PPRV) activates the innate immune response via Toll-like receptor 2 signaling.Virulence · 2021Article
- Enhanced generation of influenza-specific tissue resident memory CD8 T cells in NK-depleted mice.Scientific reports · 2021Article
- NK Cell-Based Immunotherapy and Therapeutic Perspective in Gliomas.Frontiers in oncology · 2021Review
- Article
- Tumor-Experienced Human NK Cells Express High Levels of PD-L1 and Inhibit CD8Frontiers in immunology · 2021Article
72 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 4 institutions in 1 country.
Funding
Abstract
Effective immunity requires the coordinated activation of innate and adaptive immune responses. Natural killer (NK) cells are central innate immune effectors, but can also affect the generation of acquired immune responses to viruses and malignancies. How NK cells influence the efficacy of adaptive immunity, however, is poorly understood. Here, we show that NK cells negatively regulate the duration and effectiveness of virus-specific CD4+ and CD8+ T cell responses by limiting exposure of T cells to infected antigen-presenting cells. This impacts the quality of T cell responses and the ability to limit viral persistence. Our studies provide unexpected insights into novel interplays between innate and adaptive immune effectors, and define the critical requirements for efficient control of viral persistence.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.