ArticleDevelopmental biology2010
A matrix metalloproteinase mediates airway remodeling in Drosophila.
Article in Developmental biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 58 citations in OpenAlex.
- Hypoxia-induced tracheal elasticity in vector beetle facilitates the loading of pinewood nematode.eLife · 2023Article
- The Osiris family genes function as novel regulators of the tube maturation process in the Drosophila trachea.PLoS genetics · 2023Article
- Review
- A Matrix Metalloproteinase Mediates Tracheal Development inInternational journal of molecular sciences · 2021Article
- Glycosylhydrolase genes control respiratory tubes sizes and airway stability.Scientific reports · 2020Article
- Sequential Ras/MAPK and PI3K/AKT/mTOR pathways recruitment drives basal extrusion in the prostate-like gland of Drosophila.Nature communications · 2020Article
- Disentangling geometrical, viscoelastic and hyperelastic effects in force-displacement relationships of folded biological tissues.The European physical journal. E, Soft matter · 2019Article
- The apical protein Apnoia interacts with Crumbs to regulate tracheal growth and inflation.PLoS genetics · 2019Article
- A scar-like lesion is apparent in basement membrane after wound repair in vivo.Matrix biology : journal of the International Society for Matrix Biology · 2018Article
- Decoupling from yolk sac is required for extraembryonic tissue spreading in the scuttle flyeLife · 2018Article
- Regulators of Long-Term Memory Revealed by Mushroom Body-Specific Gene Expression Profiling inGenetics · 2018Article
- Development and Function of theGenetics · 2018Review
- Both Drosophila matrix metalloproteinases have released and membrane-tethered forms but have different substrates.Scientific reports · 2017Article
- Matrix Metalloproteinases are required for membrane motility and lumenogenesis during Drosophila heart development.PloS one · 2017Article
- Synaptic roles for phosphomannomutase type 2 in a new Drosophila congenital disorder of glycosylation disease model.Disease models & mechanisms · 2016Article
- Failure to Burrow and Tunnel Reveals Roles for jim lovell in the Growth and Endoreplication of the Drosophila Larval Tracheae.PloS one · 2016Article
- Loss of Cell Adhesion Increases Tumorigenic Potential of Polarity Deficient Scribble Mutant Cells.PloS one · 2016Article
- ECM-Regulator timp Is Required for Stem Cell Niche Organization and Cyst Production in the Drosophila Ovary.PLoS genetics · 2016Article
- Transient junction anisotropies orient annular cell polarization in the Drosophila airway tubes.Nature cell biology · 2015Article
- Cortical instability drives periodic supracellular actin pattern formation in epithelial tubes.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Organ size typically increases dramatically during juvenile growth. This growth presents a fundamental tension, as organs need resiliency to resist stresses while still maintaining plasticity to accommodate growth. The extracellular matrix (ECM) is central to providing resiliency, but how ECM is remodeled to accommodate growth is poorly understood. We investigated remodeling of Drosophila respiratory tubes (tracheae) that elongate continually during larval growth, despite being lined with a rigid cuticular ECM. Cuticle is initially deposited with a characteristic pattern of repeating ridges and valleys known as taenidia. We find that for tubes to elongate, the extracellular protease Mmp1 is required for expansion of ECM between the taenidial ridges during each intermolt period. Mmp1 protein localizes in periodically spaced puncta that are in register with the taenidial spacing. Mmp1 also degrades old cuticle at molts, promotes apical membrane expansion in larval tracheae, and promotes tube elongation in embryonic tracheae. Whereas work in other developmental systems has demonstrated that MMPs are required for axial elongation occurring in localized growth zones, this study demonstrates that MMPs can also mediate interstitial matrix remodeling during growth of an organ system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.