ArticleBiophysical journal2010
Predicting local SR Ca(2+) dynamics during Ca(2+) wave propagation in ventricular myocytes.
Article in Biophysical journal, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 36 citations in OpenAlex.
- Role of ryanodine receptor cooperativity in CaThe Journal of physiology · 2024Article
- A Stochastic Spatiotemporal Model of Rat Ventricular Myocyte Calcium Dynamics Demonstrated Necessary Features for Calcium Wave Propagation.Membranes · 2021Article
- Increasing SERCA function promotes initiation of calcium sparks and breakup of calcium waves.The Journal of physiology · 2021Article
- Excitation-contraction coupling and calcium release in atrial muscle.Pflugers Archiv : European journal of physiology · 2021Review
- Pharmacological Modulation of Mitochondrial CaFrontiers in physiology · 2018Article
- Calcium Deregulation: Novel Insights to Understand Friedreich's Ataxia Pathophysiology.Frontiers in cellular neuroscience · 2018Article
- The intricacies of atrial calcium cycling during excitation-contraction coupling.The Journal of general physiology · 2017Review
- Ambiguous interactions between diastolic and SR CaThe Journal of general physiology · 2017Review
- A novel mechanism of tandem activation of ryanodine receptors by cytosolic and SR luminal CaThe Journal of physiology · 2017Article
- Numerical Approach to Spatial Deterministic-Stochastic Models Arising in Cell Biology.PLoS computational biology · 2016Article
- Dantrolene suppresses spontaneous Ca2+ release without altering excitation-contraction coupling in cardiomyocytes of aged mice.American journal of physiology. Heart and circulatory physiology · 2014Article
- Alterations in T-tubule and dyad structure in heart disease: challenges and opportunities for computational analyses.Cardiovascular research · 2013Review
- Decoding myocardial Ca²⁺ signals across multiple spatial scales: a role for sensitivity analysis.Journal of molecular and cellular cardiology · 2013Review
- Calcium movements inside the sarcoplasmic reticulum of cardiac myocytes.Journal of molecular and cellular cardiology · 2013Review
- Ca²⁺ waves in the heart.Journal of molecular and cellular cardiology · 2013Review
- Facilitation of cytosolic calcium wave propagation by local calcium uptake into the sarcoplasmic reticulum in cardiac myocytes.The Journal of physiology · 2012Article
- β-Adrenergic stimulation increases the intra-sarcoplasmic reticulum Ca2+ threshold for Ca2+ wave generation.The Journal of physiology · 2012Article
- Computational approaches to understand cardiac electrophysiology and arrhythmias.American journal of physiology. Heart and circulatory physiology · 2012Review
- Modelling cardiac calcium sparks in a three-dimensional reconstruction of a calcium release unit.The Journal of physiology · 2012Article
- How cells process information: quantification of spatiotemporal signaling dynamics.Protein science : a publication of the Protein Society · 2012Review
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Of the many ongoing controversies regarding the workings of the sarcoplasmic reticulum (SR) in cardiac myocytes, two unresolved and interconnected topics are 1), mechanisms of calcium (Ca(2+)) wave propagation, and 2), speed of Ca(2+) diffusion within the SR. Ca(2+) waves are initiated when a spontaneous local SR Ca(2+) release event triggers additional release from neighboring clusters of SR release channels (ryanodine receptors (RyRs)). A lack of consensus regarding the effective Ca(2+) diffusion constant in the SR (D(Ca,SR)) severely complicates our understanding of whether dynamic local changes in SR [Ca(2+)] can influence wave propagation. To address this problem, we have implemented a computational model of cytosolic and SR [Ca(2+)] during Ca(2+) waves. Simulations have investigated how dynamic local changes in SR [Ca(2+)] are influenced by 1), D(Ca,SR); 2), the distance between RyR clusters; 3), partial inhibition or stimulation of SR Ca(2+) pumps; 4), SR Ca(2+) pump dependence on cytosolic [Ca(2+)]; and 5), the rate of transfer between network and junctional SR. Of these factors, D(Ca,SR) is the primary determinant of how release from one RyR cluster alters SR [Ca(2+)] in nearby regions. Specifically, our results show that local increases in SR [Ca(2+)] ahead of the wave can potentially facilitate Ca(2+) wave propagation, but only if SR diffusion is relatively slow. These simulations help to delineate what changes in [Ca(2+)] are possible during SR Ca(2+)release, and they broaden our understanding of the regulatory role played by dynamic changes in [Ca(2+)](SR).
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