ArticleClinical cardiology2010
The association of statin use and statin type and cognitive performance: analysis of the reasons for geographic and racial differences in stroke (REGARDS) study.
Article in Clinical cardiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 45 citations in OpenAlex.
- Statins use and risk of dementia: A dose-response meta analysis.Medicine · 2018 · on this mapPooled it
- Cost-effectiveness of statins for primary cardiovascular prevention in chronic kidney disease.Journal of the American College of Cardiology · 2013Pooled it
- The Effects of Statins on Cognitive Performance Are Mediated by Low-Density Lipoprotein, C-Reactive Protein, and Blood Glucose Concentrations.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023Article
- The Associations of Loneliness and Social Support with Cognitive Impairment among Middle-Aged and Older Individuals with Diabetes.International journal of environmental research and public health · 2023Article
- Statins and Cognitive Decline in the Cardiovascular Health Study: A Comparison of Different Analytical Approaches.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Article
- Vascular-brain Injury Progression after Stroke (VIPS) study: concept for understanding racial and geographic determinants of cognitive decline after stroke.Journal of the neurological sciences · 2020Review
- Cognitive Function Assessment in Patients on Moderate- or High-Intensity Statin Therapy.Journal of clinical medicine research · 2020Article
- Impact of Statin Use on Dementia Incidence in Elderly Men and Women with Ischemic Heart Disease.Biomedicines · 2020Article
- Effect of Combined Antihypertensive and Lipid-Lowering Therapies on Cognitive Function: A New Treatment Strategy?Cardiology research and practice · 2020Review
- PCSK9 Variants, Low-Density Lipoprotein Cholesterol, and Neurocognitive Impairment: Reasons for Geographic and Racial Differences in Stroke Study (REGARDS).Circulation · 2018Article
- Article
- Association of Cognitive Impairment in Patients on 3-Hydroxy-3-Methyl-Glutaryl-CoA Reductase Inhibitors.Journal of clinical medicine research · 2017Article
- Statin use and cognitive function in middle-aged adults with type 1 diabetes.World journal of diabetes · 2017Article
- Overcoming Challenges With Statin Therapy.Journal of the American Heart Association · 2016Review
- Coronary heart disease risk factors and outcomes in the twenty-first century: findings from the REasons for Geographic and Racial Differences in Stroke (REGARDS) Study.Current hypertension reports · 2015Review
- Statins and cognitive function: an updated review.Current cardiology reports · 2015Review
- Cognitive effects of statin medications.CNS drugs · 2014Review
- Neuropsychiatric adverse events associated with statins: epidemiology, pathophysiology, prevention and management.CNS drugs · 2014Review
- Statin use and cognitive function: population-based observational study with long-term follow-up.PloS one · 2014Observational
- Benefits & risks of statin therapy for primary prevention of cardiovascular disease in Asian Indians - a population with the highest risk of premature coronary artery disease & diabetes.The Indian journal of medical research · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundStatin use and type have been variably associated with impaired or improved cognitive performance. HYPOTHESIS: To assess the association of statin use and type (lipophilic vs hydrophilic) and cognitive impairment.
methodsCross-sectional analysis of 24 595 participants (7191 statin users and 17 404 nonusers) age > or = 45 years, from a population-based national cohort study (Reasons for Geographic And Racial Differences in Stroke) enrolled between January 2003 and October 2008, with oversampling from the southeastern Stroke Belt and African Americans. Statin use and type were documented in participants' homes by a trained health professional. Cognitive performance was assessed with a prior validated instrument of global cognitive status (Six-Item Screener). Cognitive impairment was defined as a score of < 4.
resultsOverall, an association of cognitive impairment and statin use was observed (8.6% of users vs 7.7% of nonusers had cognitive impairment, P = 0.014); but, after adjusting for variables known to be associated with cognition (age, gender, race, income, education level, and cardiovascular disease), the association was attenuated (odds ratio [OR]: 0.98, confidence interval [CI]: 0.87-1.10). No association was observed between statin type (lipophilic vs hydrophilic) and cognition (OR: 1.03, CI: 0.86-1.24), and there were no regional differences in cognitive impairment in statin users (8% in the Stroke Belt and 7.9% in other regions, P = 0.63).
conclusionsStatin use and type were marginally associated with cognitive impairment. After adjusting for known variables that affect cognition, no association was observed. No regional differences were observed. This large study found no evidence to support an association between statins and cognitive performance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.