ArticleProtein science : a publication of the Protein Society2010
Functional rules for lac repressor-operator associations and implications for protein-DNA interactions.
Article in Protein science : a publication of the Protein Society, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 31 citations in OpenAlex.
- Review
- Computational design of sequence-specific DNA-binding proteins.Nature structural & molecular biology · 2025Article
- Rugged fitness landscapes minimize promiscuity in the evolution of transcriptional repressors.Cell systems · 2024Article
- Next generation synthetic memory via intercepting recombinase function.Nature communications · 2023Article
- TReSR: A PCR-compatible DNA sequence design method for engineering proteins containing tandem repeats.PloS one · 2023Article
- Engineered signal-coupled inducible promoters: measuring the apparent RNA-polymerase resource budget.Nucleic acids research · 2020Article
- Engineered systems of inducible anti-repressors for the next generation of biological programming.Nature communications · 2020Article
- Transcriptional programming using engineered systems of transcription factors and genetic architectures.Nature communications · 2019Article
- Mapping DNA sequence to transcription factor binding energy in vivo.PLoS computational biology · 2019Article
- The LacI-Family Transcription Factor, RbsR, Is a Pleiotropic Regulator of Motility, Virulence, Siderophore and Antibiotic Production, Gas Vesicle Morphogenesis and Flotation inFrontiers in microbiology · 2017Article
- Regulation of Streptococcus mutans PTS Bio by the transcriptional repressor NigR.Molecular oral microbiology · 2015Article
- A quantitative understanding of lac repressor's binding specificity and flexibility.Quantitative biology (Beijing, China) · 2015Article
- High-resolution specificity from DNA sequencing highlights alternative modes of Lac repressor binding.Genetics · 2014Article
- Comparative genomics and evolution of regulons of the LacI-family transcription factors.Frontiers in microbiology · 2014Article
- Tuning response curves for synthetic biology.ACS synthetic biology · 2013Article
- Local gene regulation details a recognition code within the LacI transcriptional factor family.PLoS computational biology · 2010Article
- Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The Lac repressor has been used as a tool to understand protein-DNA recognition for many years. Recent experiments have demonstrated the ability of the Lac repressor to control gene expression in various eukaryotic systems, making the quest for an arsenal of protein-DNA binding partners desirable for potential therapeutic applications. Here, we present the results of the most exhaustive screen of Lac repressor-DNA binding partners to date, resulting in the elucidation of functional rules for Lac-DNA binding. Even within the confines of a single protein-DNA scaffold, modes of binding of different protein-DNA partners are sufficiently diverse so as to prevent elucidation of generalized rules for recognition for a single protein, much less an entire protein family.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.