ArticlePediatric nephrology (Berlin, Germany)2010
Etiology and outcome of acute kidney injury in children.
Article in Pediatric nephrology (Berlin, Germany), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 55 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
European Registry of Dialysis Treatment of Pediatric Acute Kidney Injury (AKI)
Predictors of Acute Kidney Injury in Critically Ill Children Admitted to Pediatrics Intensive Care Unit At Assiut University Children Hospital.
Who cites it
55 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The Japanese clinical practice guideline for acute kidney injury 2016.Clinical and experimental nephrology · 2018Guideline
- Systematic Literature Review on the Incidence and Prevalence of Heart Failure in Children and Adolescents.Pediatric cardiology · 2018Pooled it
- Early, frequent, yet reversible: acute kidney injury after hematopoietic stem cell transplantation in pediatric Fanconi anemia and long-term renal outcomes.Pediatric nephrology (Berlin, Germany) · 2026Article
- Blood transfusion in pediatric sepsis-associated acute kidney injury: a nationwide study of risk factors and outcomes.Pediatric nephrology (Berlin, Germany) · 2026Article
- Dynamic Regulation of Ferroptosis in a Neonatal Rat Model of Postnatal Hypoxia-Induced Acute Kidney Injury.Antioxidants (Basel, Switzerland) · 2026Article
- Pediatric acute kidney injury: what do we know about etiology and recovery?Childhood kidney diseases · 2026Article
- Epidemiology and outcome of pediatric acute kidney injury-multicenter observational study from a low-middle-income country.Pediatric nephrology (Berlin, Germany) · 2025Observational
- The relevance of acute kidney injury in dehydrated children.Frontiers in pediatrics · 2025Review
- Pediatric severe sepsis: epidemiology and risk factors associated with acute kidney injury.Frontiers in pediatrics · 2025Article
- A Multi-Pathogen Retrospective Study in Patients Hospitalized for Acute Gastroenteritis.Diseases (Basel, Switzerland) · 2024Article
- Acute Kidney Injury in Children: A Focus for the General Pediatrician.Children (Basel, Switzerland) · 2024Review
- Epidemiology of childhood acute kidney injury in England using e-alerts.Clinical kidney journal · 2023Article
- Acute kidney injury and diabetic kidney disease in children with acute complications of diabetes.Pediatric nephrology (Berlin, Germany) · 2023Article
- Choline supplementation attenuates experimental sepsis-associated acute kidney injury.American journal of physiology. Renal physiology · 2022Article
- Olfactomedin 4 as a novel loop of Henle-specific acute kidney injury biomarker.Physiological reports · 2022Article
- Predictive ability of renal angina index alone or in combination with biomarkers for detection of acute kidney injury in children.Pediatric nephrology (Berlin, Germany) · 2022Article
- Acute kidney injury in children hospitalized for acute gastroenteritis: prevalence and risk factors.Pediatric nephrology (Berlin, Germany) · 2021Article
- Childhood risk factors for adulthood chronic kidney disease.Pediatric nephrology (Berlin, Germany) · 2021Review
- Pediatric acute kidney injury: new advances in the last decade.Kidney research and clinical practice · 2021Article
- Childhood Cancer and the Risk of ESKD.Journal of the American Society of Nephrology : JASN · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this prospective, multicenter study was to define the etiology and clinical features of acute kidney injury (AKI) in a pediatric patient cohort and to determine prognostic factors. Pediatric-modified RIFLE (pRIFLE) criteria were used to classify AKI. The patient cohort comprised 472 pediatric patients (264 males, 208 females), of whom 32.6% were newborns (median age 3 days, range 1-24 days), and 67.4% were children aged >1 month (median 2.99 years, range 1 month-18 years). The most common medical conditions were prematurity (42.2%) and congenital heart disease (CHD, 11.7%) in newborns, and malignancy (12.9%) and CHD (12.3%) in children aged >1 month. Hypoxic/ischemic injury and sepsis were the leading causes of AKI in both age groups. Dialysis was performed in 30.3% of newborns and 33.6% of children aged >1 month. Mortality was higher in the newborns (42.6 vs. 27.9%; p < 0.005). Stepwise multiple regression analysis revealed the major independent risk factors to be mechanical ventilation [relative risk (RR) 17.31, 95% confidence interval (95% CI) 4.88-61.42], hypervolemia (RR 12.90, 95% CI 1.97-84.37), CHD (RR 9.85, 95% CI 2.08-46.60), and metabolic acidosis (RR 7.64, 95% CI 2.90-20.15) in newborns and mechanical ventilation (RR 8.73, 95% CI 3.95-19.29), hypoxia (RR 5.35, 95% CI 2.26-12.67), and intrinsic AKI (RR 4.91, 95% CI 2.04-11.78) in children aged >1 month.
Indexed as
Identifiers
20512652What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.