ArticleMolecular and cellular biochemistry2010
Involvement of GSK-3β in attenuation of the cardioprotective effect of ischemic preconditioning in diabetic rat heart.
Article in Molecular and cellular biochemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 69 citations in OpenAlex.
- Chrysin restores the cardioprotective effect of ischemic preconditioning in diabetes-challenged rat heart.Heliyon · 2023Article
- Modulation ofJournal of pharmacopuncture · 2022Article
- Influence of Hyperglycemia and Diabetes on Cardioprotection by Humoral Factors Released after Remote Ischemic Preconditioning (RIPC).International journal of molecular sciences · 2021Article
- An inquest into regulatory mechanism of caveolin by ischemic preconditioning against orchidectomy-challenged rat heart.Molecular and cellular biochemistry · 2021Article
- Remote liver ischemic preconditioning attenuates myocardial ischemia/reperfusion injury in streptozotocin-induced diabetic rats.Scientific reports · 2021Article
- Effect of hyperglycaemia and diabetes on acute myocardial ischaemia-reperfusion injury and cardioprotection by ischaemic conditioning protocols.British journal of pharmacology · 2020Review
- Review
- Extracellular Vesicles Derived from Hypoxic Human Mesenchymal Stem Cells Attenuate GSK3β Expression via miRNA-26a in an Ischemia-Reperfusion Injury Model.Yonsei medical journal · 2018Article
- An overview of protective strategies against ischemia/reperfusion injury: The role of hyperbaric oxygen preconditioning.Brain and behavior · 2018Review
- Ameliorative potential of conditioning on ischemia-reperfusion injury in diabetes.Conditioning medicine · 2018Article
- Myocyte membrane and microdomain modifications in diabetes: determinants of ischemic tolerance and cardioprotection.Cardiovascular diabetology · 2017Review
- Ischemic preconditioning: Interruption of various disorders.Journal of the Saudi Heart Association · 2017Review
- Hydrosulfide attenuates acute myocardial ischemic injury through the glycogen synthase kinase-3β/β-catenin signaling pathway.International journal of molecular medicine · 2016Article
- Role of Neu-p11/luzindole in the regulation of insulin signaling pathways and insulin resistance.Acta biochimica et biophysica Sinica · 2016Article
- Experimental Diabetes Mellitus in Different Animal Models.Journal of diabetes research · 2016Review
- Chronic Hyperinsulinemia Causes Selective Insulin Resistance and Down-regulates Uncoupling Protein 3 (UCP3) through the Activation of Sterol Regulatory Element-binding Protein (SREBP)-1 Transcription Factor in the Mouse Heart.The Journal of biological chemistry · 2015Article
- Punicalagin, an active component in pomegranate, ameliorates cardiac mitochondrial impairment in obese rats via AMPK activation.Scientific reports · 2015Article
- Contribution of apoptosis in myocardial reperfusion injury and loss of cardioprotection in diabetes mellitus.The journal of physiological sciences : JPS · 2015Review
- Pre-germinated brown rice prevents high-fat diet induced hyperglycemia through elevated insulin secretion and glucose metabolism pathway in C57BL/6J strain mice.Journal of clinical biochemistry and nutrition · 2015Article
- The challenge of translating ischemic conditioning from animal models to humans: the role of comorbidities.Disease models & mechanisms · 2014Review
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ischemic preconditioning (IPC) produces cardioprotection by phosphorylation of glycogen synthase kinase-3β (GSK-3β) that inhibits the opening of mitochondrial permeability transition pore (MPTP). The activity of glycogen GSK-3β is elevated during diabetes mellitus (DM). This study investigated the role of GSK-3β in attenuation of cardioprotective effect of IPC in diabetic rat. DM was induced by single administration of streptozotocin (STZ, 50 mg/kg, i.p.). Isolated perfused heart was subjected to 30 min of ischemia followed by 120 min of reperfusion. Myocardial infarct size was estimated by triphenyltetrazolium chloride (TTC) staining and lactate dehydrogenase (LDH) and creatine kinase-MB (CK-MB) was analyzed in coronary effluent. IPC significantly decreased myocardial infarct size and release of LDH and CK-MB from normal rat heart. The cardioprotective effect of IPC was significantly attenuated in diabetic rat. Four episodes of preconditioning by either of GSK-3β inhibitors, lithium chloride (LiCl, 20 mM), indirubin-3 monooxime (1 μM), and SB216763 (3 μM) significantly reduced the LDH and CK-MB release and decreased infarct size in diabetic rat heart. Perfusion of atractyloside, an opener of MPTP, significantly attenuated, the cardioprotective effect of IPC in normal rat heart, and of GSK-3β inhibitor induced preconditioning in the DM rat heart. Our results suggest that preconditioning with GSK-3β inhibitors in diabetic rat heart may provide a more consistent cardioprotection, as compared to IPC. Also, the mechanism of diabetes mellitus-induced attenuation of cardioprotective effect of IPC involves activation of GSK-3β, due to impaired protective upstream signaling pathways and opening of MPTP during reperfusion.
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