Evidence map›Paper›PMID 20512584›Full record

Trial reportEuropean journal of applied physiology2010

Enhanced neural drive after maximal strength training in multiple sclerosis patients.

Marius S Fimland, Jan Helgerud, Markus Gruber, Gunnar Leivseth, Jan Hoff

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in European journal of applied physiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 5 pooled it
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 5 syntheses or guidelines pooled it, 103 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Exercise therapy for fatigue in multiple sclerosis.The Cochrane database of systematic reviews · 2015
    Pooled it
  5. Pooled it
  6. Trial
  7. Trial
  8. Trial
  9. Effect of a Combined Program of Strength and Dual Cognitive-Motor Tasks in Multiple Sclerosis Subjects.International journal of environmental research and public health · 2020
    Trial
  10. Trial
  11. Trial
  12. Trial
  13. Article
  14. Beneficial impact of physical activity on multiple sclerosis disability progression.Journal of neurology, neurosurgery, and psychiatry · 2026
    Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Marius S FimlandDepartment of Circulation and Medical Imaging, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway. marius.steiro.fimland@stolav.no
Jan Helgerud
Markus Gruber
Gunnar Leivseth
Jan Hoff
Norwegian University of Science and Technology · NOSt Olav's University Hospital · NOUniversity of Potsdam · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multiple sclerosis (MS) patients suffer from impaired muscle activation and lower limb strength. Strength training enhances muscle activation and muscle strength, but neural adaptations to strength training remain unexplored in MS patients. The hypothesis was that maximal strength training (MST) using high loads and few repetitions would improve central neural drive and thus strength capacity of MS patients. 14 MS patients staying at a national MS rehabilitation center were randomly assigned to a MST group or a control group (CG). Both groups received "today's treatment". In addition, the MST group trained 4 x 4 repetitions of unilateral dynamic leg press and plantar flexion 5 days a week for 3 weeks. Neural adaptations of the soleus muscle were assessed by surface electromyography (EMG) activity, and by superimposed H-reflexes and V-waves obtained during maximum voluntary isometric plantar flexor contractions (MVCs). H-reflexes and V-waves were normalized by the M-wave (H(SUP)/M(SUP), V/M(SUP), respectively). In the MST group, MVC increased by 20 +/- 9% (P < 0.05). Soleus EMG activity and V/M(SUP) ratio increased by 40 and 55%, respectively, in the MST group compared to the CG (P <or= 0.05). The H(SUP)/M(SUP) ratio remained unchanged. No change was apparent in the CG. MST group subjects were able to complete all training sessions. No adverse effects were reported. This randomized study provides evidence that MST is effective of augmenting the magnitude of efferent motor output of spinal motor neurons in MS patients, alleviating some neuromuscular symptoms linked to the disease.

Indexed as

Isometric ContractionMotor NeuronsMuscle StrengthResistance TrainingAdaptation, PhysiologicalAdultAgedElectromyographyEvoked Potentials, MotorFemaleH-ReflexHumansLower ExtremityMaleMiddle AgedMultiple Sclerosis

Identifiers

PMID20512584
OpenAlexW2128607733

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.