ArticleObesity surgery2010
Obesity and insulin resistance-related changes in the expression of lipogenic and lipolytic genes in morbidly obese subjects.
Article in Obesity surgery, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 57 citations in OpenAlex.
- Trial
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- Oxidized LDL Increase the Proinflammatory Profile of Human Visceral Adipocytes Produced by Hypoxia.Biomedicines · 2021Article
- Oleic Acid Protects Against Insulin Resistance by Regulating the Genes Related to the PI3K Signaling Pathway.Journal of clinical medicine · 2020Article
- Review
- Changes in adipose tissue lipolysis gene expression and insulin sensitivity after weight loss.Endocrine connections · 2020Article
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- Metabolically Healthy Obesity and Bariatric Surgery.Obesity surgery · 2019Review
- Growth hormone-releasing hormone is produced by adipocytes and regulates lipolysis through growth hormone receptor.International journal of obesity (2005) · 2017Article
- Pathogenesis of nonalcoholic steatohepatitis.Cellular and molecular life sciences : CMLS · 2016Review
- Metabolic health and weight: Understanding metabolically unhealthy normal weight or metabolically healthy obese patients.Metabolism: clinical and experimental · 2016Article
- Downregulation of de Novo Fatty Acid Synthesis in Subcutaneous Adipose Tissue of Moderately Obese Women.International journal of molecular sciences · 2015Article
- The expression of genes involved in jejunal lipogenesis and lipoprotein synthesis is altered in morbidly obese subjects with insulin resistance.Laboratory investigation; a journal of technical methods and pathology · 2015Article
- Gene expression of different adipose tissues of severely obese women with or without a dysmetabolic profile.Journal of physiology and biochemistry · 2015Article
- Hypoxia is associated with a lower expression of genes involved in lipogenesis in visceral adipose tissue.Journal of translational medicine · 2015Article
- Impaired adipose tissue expandability and lipogenic capacities as ones of the main causes of metabolic disorders.Journal of diabetes research · 2015Review
- Omental adipose tissue gene expression, gene variants, branched-chain amino acids, and their relationship with metabolic syndrome and insulin resistance in humans.Genes & nutrition · 2014Article
- Does dietary iodine regulate oxidative stress and adiponectin levels in human breast milk?Antioxidants & redox signaling · 2014Article
- Raised serum TSH in morbid-obese and non-obese patients: effect on the circulating lipid profile.Endocrine · 2014Article
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe storage capacity of adipose tissue may be an important factor linking obesity, insulin resistance (IR), and associated morbidities. The aim of this study was to analyze the expression of lipogenic and lipolytic genes in adipose tissue and the influence of IR.
methodsWe studied the mRNA expression of peroxisome proliferator-activated receptor-γ (PPARγ) and lipogenic and lipolytic enzymes in the visceral (VAT) and subcutaneous adipose tissue (SAT) from 23 morbidly obese patients (MO; 13 with low IR and ten with high IR) and from 15 healthy, lean controls.
resultsIn the VAT and SAT from the MO, we found an increased expression of PPARγ (p = 0.001 and p = 0.022, respectively), acyl-coenzyme A (CoA)/cholesterol acyltransferase (p < 0.001 and p < 0.001), aquaporin 7 (p < 0.001 and p = 0.003), and adipose triglyceride lipase (p < 0.001 and p < 0.001) and a reduced expression of acetyl-coenzyme A carboxylase (p = 0.004 and p < 0.001), independently of the state of IR. The expression of phosphoenolpyruvate carboxykinase and acyl-CoA synthetase, however, was significantly lower in the MO with high IR (p < 0.05). Glycerol kinase (p = 0.010), hormone-sensitive lipase (p < 0.001), and perilipin (p = 0.006) were only significantly increased in VAT. Acyl-CoA synthetase (p = 0.012) and fatty acid binding protein-4 (p = 0.003) were only significantly decreased in SAT. The expression of the genes studied was only greater in the SAT than the VAT in the controls.
conclusionOur results show an upregulation of genes facilitating triglyceride/fatty acid cycling and a reduction in the genes involved in de novo synthesis of fatty acids in morbid obesity. The expression of some of the genes studied seems to be related with the state of IR. VAT and SAT differ metabolically and also between controls and MO.
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