Evidence map›Paper›PMID 20512364›Full record

ReviewBrain structure & function2010

The insula and drug addiction: an interoceptive view of pleasure, urges, and decision-making.

Nasir H Naqvi, Antoine Bechara

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Brain structure & function, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 322 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
322citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

322 citing papers in PubMed, 8 syntheses or guidelines pooled it.

  1. Pooled it
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  9. Connectome-based encoding of subjective drug responses to acute oral methamphetamine.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025
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  14. Neural correlates of inhibitory control are associated with stimulant-like effects of alcohol.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021
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  18. Nicotine Increases Activation to Anticipatory Valence Cues in Anterior Insula and Striatum.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2018
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262 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Nasir H NaqviDepartment of Psychiatry, Columbia University and New York State Psychiatric Institute, New York, NY 10032, USA. nhn2102@columbia.edu
Antoine Bechara

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007337 · NIGMS · UNIVERSITY OF IOWA · PI GEYER, PAMELA K., LENTZ, STEVEN R · 1985 to 2020
$15.9M
PRIMING THE PUMP: TRAINING PHYSICIAN-SCIENTISTS IN TRANSLATIONAL PSYCHIATRYR25MH086466 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI Melissa Arbuckle, Eduardo David Leonardo · 2009 to 2026
$4.3M
Changes in Addictive Behaviors After Brain LesionsR01DA023051 · NIDA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BECHARA, ANTOINE · 2008 to 2012
$2.4M
NIDA NIH HHS R01 DA023051NIGMS NIH HHS T32 GM007337NIMH NIH HHS R25 MH086466
6 · The paper itself

Abstract

We have recently shown that damage to the insula leads to a profound disruption of addiction to cigarette smoking (Naqvi et al., Science 315:531-534, 2007). Yet, there is little understanding of why the insula should play such an important role in an addictive behavior. A broad literature (much of it reviewed in this issue) has addressed the role of the insula in processes related to conscious interoception, emotional experience, and decision-making. Here, we review evidence for the role of the insula in drug addiction, and propose a novel theoretical framework for addiction in which the insula represents the interoceptive effects of drug taking, making this information available to conscious awareness, memory and executive functions. A central theme of this framework is that a primary goal for the addicted individual is to obtain the effects of the drug use ritual upon the body, and representations of this goal in interoceptive terms by the insula contribute to how addicted individuals feel, remember, and decide about taking drugs. This makes drug addiction like naturally motivated behaviors, such as eating and sex, for which an embodied ritual is the primary goal.

Indexed as

Self ConceptAnimalsAwarenessCerebral CortexHumansImpulsive BehaviorPleasureSubstance-Related Disorders

Identifiers

PMID20512364
PMCPMC3698865

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.