ReviewSao Paulo medical journal = Revista paulista de medicina2009
Y chromosome in Turner syndrome: review of the literature.
Review in Sao Paulo medical journal = Revista paulista de medicina, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 93 citations in OpenAlex.
- Germ Cell Tumors in Dysgenetic Gonads.Clinics (Sao Paulo, Brazil) · 2019Pooled it
- [Turner syndrome and genetic polymorphism: a systematic review].Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao PauloPooled it
- Gonadal dysgenesis is associated with worse outcomes in patients with ovarian nondysgerminomatous tumors: A report of the Children's Oncology Group AGCT 0132 study.Pediatric blood & cancer · 2018Trial
- Prenatal diagnosis, genetic analysis, and pregnancy outcomes of fetuses with mosaic isodicentric Y chromosomes.Molecular cytogenetics · 2026Article
- A case report on atypical chromosomal variations in Turner syndrome.Molecular cytogenetics · 2026Article
- Congenital Clitoromegaly With Concurrent Congenital Adrenal Hyperplasia and Turner Syndrome: A Case Report.Clinical medicine insights. Endocrinology and diabetes · 2026Article
- Cell Cycle Kinetics and Sister Chromatid Exchange in Mosaic Turner Syndrome.Life (Basel, Switzerland) · 2024Article
- Optical genome mapping for detection of chromosomal aberrations in prenatal diagnosis.Acta obstetricia et gynecologica Scandinavica · 2023Article
- Article
- Y Chromosome Genes May Play Roles in the Development of Neural Rosettes from Human Embryonic Stem Cells.Stem cell reviews and reports · 2022Article
- Clinical and molecular cytogenetic findings and pregnancy outcomes of fetuses with isochromosome Y.Molecular cytogenetics · 2022Article
- Searching chromosome mosaicisms in 45,X Turner syndrome: how relevant is it?Archives of endocrinology and metabolism · 2021Article
- Mediastinal germ cell tumors: many questions and perhaps an answer.The Journal of clinical investigation · 2020Article
- Human germ cell tumours from a developmental perspective.Nature reviews. Cancer · 2019Review
- Left-sided congenital heart lesions in mosaic Turner syndrome.Molecular genetics and genomics : MGG · 2018Article
- Combination of Gonadal Dysgenesis and Monosomy X with a Novo Translocation (13,14).Case reports in endocrinology · 2018Article
- Identification of Y-Chromosome Sequences in Turner Syndrome.Indian journal of pediatrics · 2016Article
- Identification of small marker chromosomes using microarray comparative genomic hybridization and multicolor fluorescent in situ hybridization.Molecular cytogenetics · 2016Article
- Mixed gonadal dysgenesis in 45,X Turner syndrome with SRY gene.Annals of pediatric endocrinology & metabolism · 2015Article
- The lymphatic phenotype in Turner syndrome: an evaluation of nineteen patients and literature review.European journal of human genetics : EJHG · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Turner syndrome (TS) is one of the most common types of aneuploidy among humans, and is present in 1:2000 newborns with female phenotype. Cytogenetically, the syndrome is characterized by sex chromosome monosomy (45,X), which is present in 50-60% of the cases. The other cases present mosaicism, with a 45,X cell line accompanied by one or more other cell lines with a complete or structurally abnormal X or Y chromosome. The presence of Y-chromosome material in patients with dysgenetic gonads increases the risk of gonadal tumors, especially gonadoblastoma. The greatest concern is the high risk of developing gonadoblastoma or other tumors and virilization during puberty if chromosome Y-specific sequences are present. The role of the Y chromosome in human oncogenesis is still controversial. Even though gonadoblastoma is a benign tumor, it can undergo transformation into invasive dysgerminoma in 60% of the cases, and also into other, malignant forms of germ cell tumors. Although some authors have questioned the high incidence of gonadoblastoma (around 30%), the risk of developing any kind of gonadal lesion, whether tumoral or not, justifies investigation of Y-chromosome sequences by means of the polymerase chain reaction (PCR), a highly sensitive, low-cost and easy-to-perform technique. In conclusion, mosaicism of both the X and the Y chromosome is a common finding in TS, and detection of Y-chromosome-specific sequences in patients, regardless of their karyotype, is necessary in order to prevent the development of gonadal lesions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.