Evidence map›Paper›PMID 20512122›Full record

ArticleNature biotechnology2010

Synthetic polymer coatings for long-term growth of human embryonic stem cells.

Luis G Villa-Diaz, Himabindu Nandivada, Jun Ding, Naiara C Nogueira-de-Souza, Paul H Krebsbach, K Sue O'Shea, Joerg Lahann, Gary D Smith

Abstract read
In one paragraph

Article in Nature biotechnology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 145 papers.

0numbers the graph read from it
0cells of the map it votes in
145citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

145 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Extracellular-Matrix-Mimetic Hydrogels by Using Nanomaterials.International journal of molecular sciences · 2025
    Review
  6. Article
  7. Article
  8. Review
  9. Review
  10. Advancements in theFrontiers in toxicology · 2025
    Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article

85 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Luis G Villa-DiazDepartment of Obstetrics and Gynecology, University of Michigan, Ann Arbor, Michigan, USA.
Himabindu Nandivada
Jun Ding
Naiara C Nogueira-de-Souza
Paul H Krebsbach
K Sue O'Shea
Joerg Lahann
Gary D Smith

Funding

Tissue Engineering and RegenerationT32DE007057 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DAVID H. KOHN · 1985 to 2026
$17.3M
Osteoblast Lineage Progression from Embryonic Stem CellsR01DE016530 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KAARTINEN, VESA M · 2005 to 2016
$3.9M
Michigan Center for hES Cell ResearchP20GM069985 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI O'SHEA, K SUE SUE · 2003 to 2006
$3.0M
NIDCR NIH HHS R01 DE016530NIDCR NIH HHS T32 DE 07057NIGMS NIH HHS P20 GM-069985NIGMS NIH HHS P20 GM069985
6 · The paper itself

Abstract

We report a fully defined synthetic polymer coating, poly[2-(methacryloyloxy)ethyl dimethyl-(3-sulfopropyl)ammonium hydroxide] (PMEDSAH), which sustains long-term human embryonic stem (hES) cell growth in several different culture media, including commercially available defined media. The development of a standardized, controllable and sustainable culture matrix for hES cells is an essential step in elucidating mechanisms that control hES cell behavior and in optimizing conditions for biomedical applications of hES cells.

Indexed as

AnimalsCell Culture TechniquesCell ProliferationCells, CulturedCoated Materials, BiocompatibleCulture MediaEmbryonic Stem CellsFibroblastsHumansMicePolymersTime FactorsCoated Materials, BiocompatibleCulture MediaPolymers

Identifiers

PMID20512122
PMCPMC3471651

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.