ArticleNucleic acids research2010
PCFamily: a web server for searching homologous protein complexes.
Article in Nucleic acids research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Article
- Membrane protein-regulated networks across human cancers.Nature communications · 2019Article
- Reconstructing genome-wide protein-protein interaction networks using multiple strategies with homologous mapping.PloS one · 2015Article
- MoNetFamily: a web server to infer homologous modules and module-module interaction networks in vertebrates.Nucleic acids research · 2012Article
- Steric recognition of T-cell receptor contact residues is required to map mutant epitopes by immunoinformatical programmes.Immunology · 2012Article
- Virtual interactomics of proteins from biochemical standpoint.Molecular biology international · 2012Article
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Authors and funding
3 authors.
Funding
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Abstract
The proteins in a cell often assemble into complexes to carry out their functions and play an essential role of biological processes. The PCFamily server identifies template-based homologous protein complexes [called protein complex family (PCF)] and infers functional modules of the query proteins. This server first finds homologous structure complexes of the query using BLASTP to search the structural template database (11,263 complexes). PCFamily then searches the homologous complexes of the templates (query) from a complete genomic database (Integr8 with 6,352,363 protein sequences in 2274 species). According to these homologous complexes across multiple species, this sever infers binding models (e.g. hydrogen-bonds and conserved amino acids in the interfaces), functional modules, and the conserved interacting domains and Gene Ontology annotations of the PCF. Experimental results demonstrate that the PCFamily server can be useful for binding model visualizations and annotating the query proteins. We believe that the server is able to provide valuable insights for determining functional modules of biological networks across multiple species. The PCFamily sever is available at http://pcfamily.life.nctu.edu.tw.
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