Evidence map›Paper›PMID 20511582›Full record

ArticleJournal of aging and health2010

Stressors over the life course and neuroendocrine system dysregulation in Costa Rica.

Omer Gersten, William H Dow, William D Dow, Luis Rosero-Bixby

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of aging and health, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

  • Erratum issued
    Dow, William D [corrected to Dow, William H]
5 · Who and what money

Authors and funding

4 authors.

Omer GerstenNational Health Research Institutes, Institute of Population Health Sciences, Division of Health Policy Research and Development, No. 35 Keyan Road, Zhunan, Miaoli County 350, Taiwan. omer@nhri.org.tw
William H Dow
William D Dow
Luis Rosero-Bixby

Funding

Program Development (Pilot)P30AG012839 · NIA · UNIVERSITY OF CALIFORNIA BERKELEY · PI William H Dow · 1999 to 2026
$18.6M
Costa Rican Health and Retirement SurveyR01AG031716 · NIA · UNIVERSITY OF CALIFORNIA BERKELEY · PI DOW, WILLIAM H. · 2008 to 2012
$1.6M
NIA NIH HHS P30 AG012839NIA NIH HHS R01 AG031716NIA NIH HHS R01AG031716Wellcome TrustWellcome Trust 072406/Z/03/Z
6 · The paper itself

Abstract

objectiveA key aspect of the increasingly popular allostatic load (AL) framework is that stressors experienced over the entire life course result in physiological dysregulation. Although core to AL theory, this idea has been little tested, and where it has been tested, the results have been mixed.

methodThe study analyzes the Costa Rican Study on Longevity and Healthy Aging (CRELES), a new, cross-sectional, and nationally representative survey of older Costa Rican men and women (aged between 60 and 109 years). The survey period is between 2004 and 2006, and the survey has a sample size of 2,827 individuals. This article focuses on the relationship between a variety of stressors experienced over the life course and cortisol, dehydroepiandrosterone sulfate (DHEAS), epinephrine, and norepinephrine analyzed separately and in an index.

resultsThere are some links between certain stressors and worse cortisol levels, but overall, almost all of the stressors examined are not associated with riskier neuroendocrine biomarker profiles. DISCUSSION: More work is needed, in order to establish the connection between stressors experienced over the life course and resting levels of the neuroendocrine markers.

Indexed as

AgedAged, 80 and overAllostasisBiomarkersCosta RicaCross-Sectional StudiesDehydroepiandrosterone SulfateEpinephrineFemaleHumansHydrocortisoneMaleMiddle AgedNeurosecretory SystemsNorepinephrineStress, PsychologicalBiomarkersDehydroepiandrosterone SulfateEpinephrineHydrocortisoneNorepinephrine

Identifiers

PMID20511582
PMCPMC3937264

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.