ArticleAmerican journal of physiology. Heart and circulatory physiology2010
Long-term exercise training does not alter brachial and femoral artery vasomotor function and endothelial phenotype in healthy pigs.
Article in American journal of physiology. Heart and circulatory physiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Heavy and moderate interval exercise training alters low-flow-mediated constriction but does not increase circulating progenitor cells in healthy humans.Experimental physiology · 2012Trial
- The impact of repeated, local heating-induced increases in blood flow on lower limb endothelial function in young, healthy females.European journal of applied physiology · 2021Article
- Interaction of genetic background and exercise training intensity on endothelial function in mouse aorta.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2020Article
- Effect of High-Calcium Diet on Coronary Artery Disease in Ossabaw Miniature Swine With Metabolic Syndrome.Journal of the American Heart Association · 2015Article
- Transcriptome-wide RNA sequencing analysis of rat skeletal muscle feed arteries. II. Impact of exercise training in obesity.Journal of applied physiology (Bethesda, Md. : 1985) · 2014Article
- Adipose tissue and vascular phenotypic modulation by voluntary physical activity and dietary restriction in obese insulin-resistant OLETF rats.American journal of physiology. Regulatory, integrative and comparative physiology · 2014Article
- Transcriptome-wide RNA sequencing analysis of rat skeletal muscle feed arteries. I. Impact of obesity.Journal of applied physiology (Bethesda, Md. : 1985) · 2014Article
- Exercise training and vascular cell phenotype in a swine model of familial hypercholesterolaemia: conduit arteries and veins.Experimental physiology · 2014Article
- Exercise training does not increase muscle FNDC5 protein or mRNA expression in pigs.Metabolism: clinical and experimental · 2013Article
- Techniques to harvest diseased human peripheral arteries and measure endothelial function in an ex vivo model.Journal of vascular surgery · 2013Article
- Carotid inflammation is unaltered by exercise in hypercholesterolemic Swine.Medicine and science in sports and exercise · 2012Article
- Impact of exercise training on endothelial transcriptional profiles in healthy swine: a genome-wide microarray analysis.American journal of physiology. Heart and circulatory physiology · 2011Article
- Vascular effects of exercise: endothelial adaptations beyond active muscle beds.Physiology (Bethesda, Md.) · 2011Review
- Relationship between brachial and femoral artery endothelial vasomotor function/phenotype in pigs.Experimental biology and medicine (Maywood, N.J.) · 2010Article
Corrections and comments
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Authors and funding
5 authors.
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Abstract
Although the beneficial effects of exercise training on conduit artery endothelial function are well-established in animals and humans with compromised basal function, whether exercise exerts favorable effects on a healthy endothelium is inconclusive. We sought to determine whether long-term exercise training enhances endothelial function in peripheral conduit arteries of healthy pigs. Using a retrospective analysis of data collected in our laboratory (n = 127), we compared in vitro brachial and femoral artery endothelium-dependent and -independent relaxation between a group of pigs that exercise-trained for 16-20 wk and a group that remained sedentary. No differences in vasomotor function were found between the 2 groups (P > 0.05). Additionally, in a subset of pigs (n = 16), expression levels of 18 proteins that are typically associated with the atherosclerotic process were measured by immunoblot analysis of endothelial cell scrapes obtained from the brachial and femoral arteries. We found no differences (P > 0.05) in endothelial gene expression between these exercise-trained and sedentary healthy pigs. These results indicate that pigs exhibiting the classic training-induced adaptations do not demonstrate enhanced endothelium-dependent dilation nor reveal a more atheroprotected endothelial cell phenotype in their brachial and femoral arteries than their sedentary but otherwise healthy counterparts.
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