ArticleThe Journal of biological chemistry2010
Identification of an L-arabinose reductase gene in Aspergillus niger and its role in L-arabinose catabolism.
Article in The Journal of biological chemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 53 citations in OpenAlex.
- The genome-scale sugar metabolic model fromCurrent research in microbial sciences · 2026Article
- Comparative transcriptome analyses and CRISPR/Cas9-mediated functional study ofFrontiers in microbiology · 2025Article
- Dissecting the complex regulation of pentose utilization inCurrent research in microbial sciences · 2025Article
- Reconstruction of a genome-scale metabolic model and in-silico flux analysis of Aspergillus tubingensis: a non-mycotoxinogenic citric acid-producing fungus.Biotechnology for biofuels and bioproducts · 2024Article
- Genome Mining Reveals a Surprising Number of Sugar Reductases inJournal of fungi (Basel, Switzerland) · 2023Article
- Identification of an l-Arabitol Transporter fromBiomolecules · 2023Article
- Revisiting a 'simple' fungal metabolic pathway reveals redundancy, complexity and diversity.Microbial biotechnology · 2021Article
- CAZymes from the thermophilic fungus Thermoascus aurantiacus are induced by C5 and C6 sugars.Biotechnology for biofuels · 2021Article
- Characterization of d-xylose reductase, XyrB, fromBiotechnology reports (Amsterdam, Netherlands) · 2021Article
- Re-routing of Sugar Catabolism Provides a Better Insight Into Fungal Flexibility in Using Plant Biomass-Derived Monomers as Substrates.Frontiers in bioengineering and biotechnology · 2021Article
- Engineering microbial pathways for production of bio-based chemicals from lignocellulosic sugars: current status and perspectives.Biotechnology for biofuels · 2020Review
- Comparison of the paralogous transcription factors AraR and XlnR in Aspergillus oryzae.Current genetics · 2018Article
- The gold-standard genome ofStudies in mycology · 2018Article
- Understanding Functional Roles of Native Pentose-Specific Transporters for Activating Dormant Pentose Metabolism in Yarrowia lipolytica.Applied and environmental microbiology · 2018Article
- Alternative Substrate Metabolism inFrontiers in microbiology · 2018Review
- Combinatorial control of gene expression in Aspergillus niger grown on sugar beet pectin.Scientific reports · 2017Article
- The pathway intermediate 2-keto-3-deoxy-L-galactonate mediates the induction of genes involved in D-galacturonic acid utilization in Aspergillus niger.FEBS letters · 2017Article
- The transcriptional activator GaaR of Aspergillus niger is required for release and utilization of d-galacturonic acid from pectin.FEBS letters · 2016Article
- Article
- Structural features of sugars that trigger or support conidial germination in the filamentous fungus Aspergillus niger.Applied and environmental microbiology · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The first enzyme in the pathway for l-arabinose catabolism in eukaryotic microorganisms is a reductase, reducing l-arabinose to l-arabitol. The enzymes catalyzing this reduction are in general nonspecific and would also reduce d-xylose to xylitol, the first step in eukaryotic d-xylose catabolism. It is not clear whether microorganisms use different enzymes depending on the carbon source. Here we show that Aspergillus niger makes use of two different enzymes. We identified, cloned, and characterized an l-arabinose reductase, larA, that is different from the d-xylose reductase, xyrA. The larA is up-regulated on l-arabinose, while the xyrA is up-regulated on d-xylose. There is however an initial up-regulation of larA also on d-xylose but that fades away after about 4 h. The deletion of the larA gene in A. niger results in a slow growth phenotype on l-arabinose, whereas the growth on d-xylose is unaffected. The l-arabinose reductase can convert l-arabinose and d-xylose to their corresponding sugar alcohols but has a higher affinity for l-arabinose. The K(m) for l-arabinose is 54 + or - 6 mm and for d-xylose 155 + or - 15 mm.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.