ArticleBrain research2010
Distribution of 5-HT1B and 5-HT1D receptors in the inner ear.
Article in Brain research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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Who cites it
16 citing papers in PubMed, 43 citations in OpenAlex.
- Effects of adding transcutaneous vagus nerve stimulation to vestibular rehabilitation on dizziness and postural control in vestibular migraine: a randomized clinical trial.Scientific reports · 2026Trial
- Rizatriptan reduces vestibular-induced motion sickness in migraineurs.The journal of headache and pain · 2011Trial
- Migraine and auditory dysfunction: beyond comorbidity.Journal of neurology · 2026Review
- Expanding the Spectrum of Central Sensitivity Syndrome: Integrating Otologic Migraine as Otologic Central Sensitivity Syndrome.Brain sciences · 2026Review
- The Presence of Serotonin in the Vestibular System: Supporting the Use of SSRIs/SNRIs in the Treatment of Vestibular Disorders-A Narrative Review.Audiology research · 2025Review
- Review
- Risk of Vestibulocochlear Disorders in Patients with Migraine or Non-Migraine Headache.Journal of personalized medicine · 2021Article
- Vestibular migraine: the chameleon in vestibular disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021Review
- Pericytes Make Spinal Cord Breathless after Injury.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2018Review
- Current Treatment Options: Vestibular Migraine.Current treatment options in neurology · 2017Review
- The Efficacy of Venlafaxine, Flunarizine, and Valproic Acid in the Prophylaxis of Vestibular Migraine.Frontiers in neurology · 2017Article
- Is the Headache in Patients with Vestibular Migraine Attenuated by Vestibular Rehabilitation?Frontiers in neurology · 2017Article
- Vestibular Migraine in Children and Adolescents.Current pain and headache reports · 2016Review
- Vestibular migraine: the most frequent entity of episodic vertigo.Journal of neurology · 2016Review
- Distribution of 5-HTFrontiers in neurology · 2016Article
- Neurologic bases for comorbidity of balance disorders, anxiety disorders and migraine: neurotherapeutic implications.Expert review of neurotherapeutics · 2011Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
Migraine and anxiety disorders are frequently co-morbid with balance disorders. This study examined the relative distribution of subtypes of serotonin (5-HT) receptor in the inner ear of monkeys and rats. Most vestibular ganglion cells were immunoreactive for 5-HT(1B) and 5-HT(1D) receptors in macaques and rats. In the inner ear, 5-HT(1B) and 5-HT(1D) receptor immunopositivity was associated with endothelial cells of the vestibular ganglion, spiral ganglion, vestibulocochlear nerve, spiral ligament and stria vascularis. It was noteworthy that 5-HT(1B) and 5-HT(1D) receptors are expressed in parallel sites in peripheral vestibular and trigeminal systems, which may be a factor underlying the efficacy of triptans in treating migraine and migrainous vertigo. Because the vestibular ganglion and trigeminal ganglion are both within the subarachnoid space, an interaction between 5-HT(1B) and TRPV1 receptors on blood vessel and ganglion cells may also contribute to the vasospasm and the comorbid headache, dizziness, nausea and vomiting that accompany subarachnoid hemorrhage.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.