Evidence map›Paper›PMID 20510418›Full record

ArticleAtherosclerosis2010

Normative values and correlates of carotid artery intima-media thickness and carotid atherosclerosis in Andean-Hispanics: The Prevencion Study.

Catherine A Pastorius, Josefina Medina-Lezama, Fernando Corrales-Medina, Antonio Bernabé-Ortiz, Roberto Paz-Manrique, Belissa Salinas-Najarro, Zubair A Khan, Junichiro Takahashi, Gen Toshima, Humberto Zea-Diaz and 6 more

Open access · greenAbstract read
In one paragraph

Article in Atherosclerosis, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.

  1. Pooled it
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  8. Bone Mineral Density Is Positively Related to Carotid Intima-Media Thickness: Findings From a Population-Based Study in Adolescents and Premenopausal Women.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2016
    Article
  9. Carotid Intima-Media Thickness in Indonesian Subjects with Cardiovascular Disease Risk Factors Who Were Not Receiving Lipid-Lowering Agents.The International journal of angiology : official publication of the International College of Angiology, Inc · 2016
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 2 countries.

Catherine A PastoriusSanta Maria Catholic University/Santa Maria Research Institute, Arequipa, Peru.
Josefina Medina-Lezama
Fernando Corrales-Medina
Antonio Bernabé-Ortiz
Roberto Paz-Manrique
Belissa Salinas-Najarro
Zubair A Khan
Junichiro Takahashi
Gen Toshima
Humberto Zea-Diaz
Mauricio Postigo-Macdowall
Julio Chirinos-Pacheco
Francisco Ibañez
Diana A Chirinos
Hassam Saif
Julio A Chirinos
Catholic University of Santa María · PEUniversity of Pennsylvania · USUniversidad Peruana Cayetano Heredia · PE

Funding

Fogarty International Clinical Research Scholars Support Center @ Vanderbilt-AAMCR24TW007988 · FIC · VANDERBILT UNIVERSITY · PI VERMUND, STEN H. · 2007 to 2011
$27.6M
Inflammatory response to sleep apnea in obese subjectsR01HL080076 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI CHIRINOS MEDINA, JULIO ALONSO · 2006 to 2010
$3.5M
FIC NIH HHS R24 TW007988NHLBI NIH HHS R01 HL080076
6 · The paper itself

Abstract

objectivesCarotid intima-media thickness (cIMT) is an independent predictor of cardiovascular risk. Furthermore, ethnicity and gender-specific normative data are required to assess cIMT, which are not available for Andean-Hispanics. In addition, data regarding correlates of subclinical atherosclerosis in ethnic population are needed.

methodsWe studied 1448 adults enrolled in a population-based study in Peru. cIMT and carotid plaque were measured with high-resolution ultrasonography. A healthy reference sample (n=472) with no cardiovascular disease, normal weight and normal metabolic parameters was selected to establish normative cIMT values. Correlates of abnormal cIMT and carotid plaque were assessed in the entire population.

resultsIn the reference sample, 95th-percentile cIMT values were both age and gender-dependent. In stepwise regression, selected predictors of increasing cIMT were: older age, impaired fasting glucose, diabetes mellitus, higher systolic blood pressure, higher LDL-cholesterol, smoking and male gender. Predictors of carotid plaque included older age, male gender, higher systolic blood pressure, lower diastolic blood pressure and higher LDL-cholesterol. HDL-cholesterol and C-reactive protein were not associated with cIMT or carotid plaque. The lack of association with HDL-cholesterol was confirmed using high performance liquid chromatography.

conclusionsWe present ethnic-specific cut-offs for abnormal cIMT applicable to Andean-Hispanics and correlates of subclinical atherosclerosis in this population. Pending longitudinal studies, our data supports several risk associations seen in other populations and can be used to identify Andean-Hispanics at increased risk for atherosclerotic cardiovascular disease. The lack of association between HDL-C and cIMT or carotid plaque in this population requires further investigation.

Indexed as

AtherosclerosisBlood PressureCardiovascular DiseasesCarotid ArteriesCholesterol, HDLCholesterol, LDLFemaleHumansMaleMiddle AgedPeruReference ValuesRegression AnalysisRiskTunica IntimaTunica MediaCholesterol, HDLCholesterol, LDL

Identifiers

PMID20510418
PMCPMC2928715
OpenAlexW2112540118

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.