ArticleMolecular and cellular neurosciences2010
In vivo evidence for the involvement of the carboxy terminal domain in assembling connexin 36 at the electrical synapse.
Article in Molecular and cellular neurosciences, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 39 citations in OpenAlex.
- Uncovering the electrical synapse proteome in retinal neurons via in vivo proximity labeling.eLife · 2026Article
- Electrical synapse molecular diversity revealed by proximity-based proteomic discovery.bioRxiv : the preprint server for biology · 2024Article
- Regulation of Cx36 trafficking through the early secretory pathway by COPII cargo receptors and Grasp55.Cellular and molecular life sciences : CMLS · 2024Article
- Trafficking of Connexin36 (Cx36) in the early secretory pathway.bioRxiv : the preprint server for biology · 2024Article
- Phosphorylation of Connexin36 near the C-terminus switches binding affinities for PDZ-domain and 14-3-3 proteins in vitro.Scientific reports · 2020Article
- Gap junctions and hemichannels: communicating cell death in neurodevelopment and disease.BMC cell biology · 2017Review
- GAP junctional communication in brain secondary organizers.Development, growth & differentiation · 2016Review
- Chromosome loci vary by juvenile myoclonic epilepsy subsyndromes: linkage and haplotype analysis applied to epilepsy and EEG 3.5-6.0 Hz polyspike waves.Molecular genetics & genomic medicine · 2016Article
- Electrotonic Coupling in the Pituitary Supports the Hypothalamic-Pituitary-Gonadal Axis in a Sex Specific Manner.Frontiers in molecular neuroscience · 2016Article
- Connexin30.2: In Vitro Interaction with Connexin36 in HeLa Cells and Expression in AII Amacrine Cells and Intrinsically Photosensitive Ganglion Cells in the Mouse Retina.Frontiers in molecular neuroscience · 2016Article
- Optogenetic mapping of cerebellar inhibitory circuitry reveals spatially biased coordination of interneurons via electrical synapses.Cell reports · 2014Article
- Electrical synapses and their functional interactions with chemical synapses.Nature reviews. Neuroscience · 2014Review
- AII amacrine cells discriminate between heterocellular and homocellular locations when assembling connexin36-containing gap junctions.Journal of cell science · 2014Article
- Connexin36 in gap junctions forming electrical synapses between motoneurons in sexually dimorphic motor nuclei in spinal cord of rat and mouse.The European journal of neuroscience · 2014Article
- Estimating functional connectivity in an electrically coupled interneuron network.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Neuronal gap junctions: making and breaking connections during development and injury.Trends in neurosciences · 2013Review
- A cataract-causing connexin 50 mutant is mislocalized to the ER due to loss of the fourth transmembrane domain and cytoplasmic domain.FEBS open bio · 2013Article
- Gap junction-mediated electrical transmission: regulatory mechanisms and plasticity.Biochimica et biophysica acta · 2013Review
- Trafficking of gap junction channels at a vertebrate electrical synapse in vivo.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Cx50 requires an intact PDZ-binding motif and ZO-1 for the formation of functional intercellular channels.Molecular biology of the cell · 2011Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 3 countries.
Funding
Abstract
Connexin 36 (Cx36)-containing electrical synapses contribute to the timing and amplitude of neural responses in many brain regions. A Cx36-EGFP transgenic was previously generated to facilitate their identification and study. In this study we demonstrate that electrical coupling is normal in transgenic mice expressing Cx36 from the genomic locus and suggest that fluorescent puncta present in brain tissue represent distributed electrical synapses. These qualities emphasize the usefulness of the Cx36-EGFP reporter as a tool for the detailed anatomical characterization of electrical synapses in fixed and living tissue. However, though the fusion protein is able to form gap junctions between Xenopus laevis oocytes it is unable to restore electrical coupling to interneurons in the Cx36-deficient mouse. Further experiments in transgenic tissue and non-neural cell lines reveal impaired transport to the plasma membrane as the possible cause. By analyzing the functional deficits exhibited by the fusion protein in vivo and in vitro, we identify a motif within Cx36 that may interact with other trafficking or scaffold proteins and thereby be responsible for its incorporation into electrical synapses.
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Registered trials
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